The invention relates to the technical field of
fondaparinux sodium, and discloses a preparation method of
fondaparinux sodium. The method comprises the following steps that 20-30 parts of mixed acidis taken, and is poured in a reaction kettle for stirring, at a stirring state, the temperature is increased to 60 DEG C, and then is maintained at 60 DEG C, stirring is continued for 20 min, a solution is left for later use, 10-20 parts of acetyl
glucosamine, 20-23 parts of methyl
alcohol and 10-14 parts of
alkyl thiophosphate are taken in sequence, and are placed in a stirrer for full mixing, through
ion exchange resin,
reflux reaction is carried out for 10-20 hours, the
reaction temperature is controlled at 50-70 DEG C, and a material is left for later use. According to the preparation method of
fondaparinux sodium, through
sedimentation, high-purity fondaparinux
sodium is prepared, in a whole production process, through multiple
distillation and separation processes, fondaparinux
sodium impurities are removed thoroughly, obtained fondaparinux
sodium has higher purity, through a whole vacuum concentration technology, fondaparinux sodium is purer, reaction of various links is carriedout more thoroughly, the production effectiveness is guaranteed, and the high purity of fondaparinux sodium is guaranteed.