136 results about "Methylthio-ADP" patented technology

The invention relates to a hole transport layer material for an inverted perovskite solar cell, the inverted perovskite solar cell and application, the hole transport layer material is a self-assembled monomolecular layer hole transport material, and the self-assembled monomolecular layer hole transport material comprises an organic compound with the following general formula: # imgabs0 #, r1 and R2 represent independently substituted C6-C15 aryl groups, and the substituent group is a methoxy group or a methylthio group; according to the inverted perovskite cell, holes of the hole transport layer can be reduced, the film forming quality can be improved, and the defects of the lower interface of the perovskite photosensitive layer can be passivated, so that the open-circuit voltage (Voc) and the fill factor (FF) of the inverted perovskite cell are effectively improved, and the photoelectric conversion efficiency of the perovskite cell is effectively improved; and the photoelectric conversion efficiency of the perovskite solar cell is optimal.

The invention belongs to the technical field of organic synthesis, and particularly relates to a pyroxasulfone preparation method which specifically comprises the following steps: dissolving 3-(5-difluoromethoxy-1-methyl-3-trifluoromethyl-1H-pyrazol-4-ylmethylthio)-5, 5-dimethyl-2-isoxazoline serving as a raw material with a solvent, then adding a boron compound, finally dropwise adding hydrogen peroxide, and reacting at room temperature to obtain the pyroxasulfone. Reacting for several hours to obtain pyroxasulfone; the adopted boron compound is cheap and easy to obtain, so that the use of a transition metal catalyst is avoided, and the raw material cost is reduced; organic acid reagents with heavy odor are not used, waste water and solid waste are less, and the method has great advantages in the aspect of environmental protection; the method is simple to operate, free of complex treatment steps and suitable for industrial production, and when the boron compound is selected from sodium metaborate, sodium perborate or a mixture of borax and sodium metaborate, the yield and purity of the process are higher, and sulfoxide impurities are fewer.

The invention relates to a fluorescent probe for hypochlorous acid detection and a preparation method and application thereof, the chemical name of the fluorescent probe for hypochlorous acid detection is 5-butyl-10, 10-difluoro-9-(4-(methylthio) phenyl)-5-hydro-4H, 10H-9 lambda 4, 10 lambda 4-benzo [de] [1, 3, 2] oxazaboraza [6, 5-g] isoquinoline-4, 6-diketone, and the structural formula of the fluorescent probe for hypochlorous acid detection is as shown in the following formula I. The invention further discloses a preparation method of the fluorescent probe for hypochlorous acid detection. According to the fluorescent probe for hypochlorous acid detection, N-butyl-3-aldehyde-4-hydroxy-1, 8-naphthalimide and (E)-2-butyl-6-hydroxy-5-(((4-(methylthio) phenyl) imino) methyl)-1H-benzo [de] isoquinoline-1, 3 (2H)-diketone are used as raw materials, and the fluorescent probe can be used for detecting hypochlorous acid. Compared with the prior art, the fluorescent probe for hypochlorous acid detection is simple and convenient in synthesis method, simple and easily available in raw materials, good in hypochlorous acid selectivity, relatively high in sensitivity and large in Stokes shift, and has a very good application prospect in hypochlorous acid detection.

The invention discloses a gold-silver alloy nanoprobe based on double-signal cooperative detection, a preparation method and application thereof, and belongs to the technical field of sensing. Then mixing the gold nanorod, a Raman report molecule p-methylthiobenzonitrile and a chiral stimulating factor L-cysteine, and jointly incubating at room temperature to obtain a mixed solution; sequentially adding silver nitrate, chloroauric acid tetrahydrate and ascorbic acid into the mixed solution, and magnetically stirring; and placing the mixed solution under a constant temperature condition to react for a certain time, so that the gold-silver alloy shell fully grows, and finally obtaining the spiral structure alloy nanoprobe with Raman signals and CD signals. The probe realizes the dual detection functions of Raman signals and circular dichroism signals, and can detect the lactic acid concentration with high sensitivity and high selectivity by combining the specific catalytic action of the lactate oxidase, and meanwhile, the Raman signals and CD signals of the silent zone can further expand the application range of the probe.

The invention discloses a green synthesis method of 4, 6-dimethoxy-2-(methylthio) pyrimidine, which comprises the following steps of: synthesizing 4, 6-dimethoxy-2-(methylthio) pyrimidine; according to the method, 4, 6-dihydroxypyrimidine-2-sodium sulfide is taken as a raw material, low-toxicity and harmless dimethyl carbonate is taken as a methylation reagent, lewis acid is added to serve as a catalyst, a reaction is performed in a phase transfer catalyst, and a 4, 6-dimethoxy-2-methylthio pyrimidine solid is prepared. The synthesis method disclosed by the invention has the advantages of cheap raw materials, simple synthesis method and high yield, toxic and harmful reagents in a fractional step method are avoided, the used phase transfer catalyst can be recycled and reused, and the synthesis method is suitable for commercial production.

The invention provides a metal peroxide complex molecular catalyst, a preparation method and application thereof, and a continuous synthesis method of pyroxasulfone. A transition metal ion center, an organic ligand, a metal-peroxide bridged bond (M-O-O-M) and other structures are introduced into the prepared metal peroxide complex molecular catalyst, and under the synergistic effect of the structures, the prepared metal peroxide complex molecular catalyst is used for oxidizing thioether into sulfone. The catalyst has excellent selectivity and catalytic efficiency. Particularly, when the catalyst is used for catalyzing 3-[(5-difluoromethoxy-1-methyl-3-trifluoromethylpyrazole-4-yl)-methylthio]-4, 5-dihydro-5, 5-dimethyl-1, 2-isoxazole to be oxidized and synthesized into pyroxasulfone, the reaction efficiency, selectivity and safety of the oxidation reaction can be effectively improved, and therefore the preparation cost of pyroxasulfone can be further reduced advantageously, and the catalyst can be used for catalyzing 3-[(5-difluoromethoxy-1-methyl-3-trifluoromethylpyrazole-4-yl)-methylthio]-4, 5-dihydro-5, 5-dimethyl-1, 2-isoxazole to be oxidized and synthesized into pyroxasulfone.

Provided are: a water-absorbent resin composition having excellent heat resistance; a water stop material containing the water-absorbent resin composition; and a cable. This water-absorbent resin composition contains water-absorbent resin particles and a benzimidazole compound represented by general formula (1) (in formula (1), R1 represents a methyl group or a hydrogen atom, and R2 represents a methyl group, an amino group, a methylthio group, a phenyl group or a hydrogen atom). # imgabs0 #

The invention relates to a preparation method of a metal halide perovskite-coated three-dimensional cobalt porphyrin-based COFs (Covalent Organic Frameworks) composite material, which comprises the following steps: S1, reacting an aldehyde precursor with an amine precursor in a first organic solvent, and after the reaction is finished, performing post-treatment to obtain a three-dimensional cobalt porphyrin-based COFs material; wherein the aldehyde precursor is 5 ', 5 '', 5'' '', 5'' ''''-(5, 10, 15, 20-tetrayl) tetra (([1, 1': 3 ', 1 ''-terphenyl]-4, 4''-diformyl))-21H, 23H-cobalt porphyrin (II), and the amine precursor is 4, 4'-diamino terphenyl and 2 ', 5'-bis ((methylthio) methyl)-[1, 1 ': 4', 1 ''-biphenyl]-4, 4''-diamine; s2, in a second organic solvent, enabling the three-dimensional cobalt porphyrin-based COFs material to react with lead bromide, and after the reaction is finished, performing post-treatment to obtain a PbBr2 (at) 3D Co-COFs material; and S3, in a third organic solvent, carrying out a reaction on the PbBr2 (at) 3D Co-COFs material and methylamine bromide, and after the reaction is finished, carrying out post-treatment to obtain the metal halide perovskite (at) three-dimensional cobalt porphyrin-based COFs composite material. The preparation method has the advantage that the photocatalytic activity and stability are improved.

The present application relates to a process for the preparation of pyroxasulfone comprising reacting 3-[(5-difluoromethoxy-1-methyl-3-trifluoromethylpyrazol-4-yl) methylthio]-4, 5-dihydro-5, 5-dimethylisoxazole with hydrogen peroxide in the presence of a metal catalyst wherein the solvent comprises at least one carbonate and water.

The utility model discloses a production system of 1-cyclopropyl-3-(2-methylthio-4-trifluoromethylphenyl) propyl-1, 3-diketone, which comprises an esterification unit and a condensation unit, and is characterized in that the esterification unit is connected with the condensation unit; the production system has the advantages that the production system is simple in connection structure and easy to implement, methyl 2-methylthio-4-trifluoromethyl benzoate is prepared from 2-methylthio-4-trifluoromethyl benzoic acid and the like through an esterification unit and then reacts with cyclopropyl ketone and other raw materials to prepare 1-cyclopropyl-3-(2-(methylthio)-4-(trifluoromethyl) phenyl) propyl-1, 3-diketone, and the production system has the advantages that the production system is simple in connection structure and easy to implement. The generation of three wastes is reduced, and the production cost is reduced; moreover, in the reaction process, the reaction temperature is not high, the reaction condition is mild, the yield is high, the production cost is low, the content of impurities in the product 1-cyclopropyl-3-(2-(methylthio)-4-(trifluoromethyl) phenyl) propyl-1, 3-diketone can be reduced, a high-quality reaction raw material is provided for subsequent industrial production of isoxaflutole, and the method is suitable for large-scale industrial production.

The application belongs to the field of microorganism and fermentation engineering, and provides a Candida magnoliae with high yield of 3-methylthiopropanol, and the preservation number is CGMCC NO. 23668. The Candida magnoliae can be used for producing 3-methylthiopropanol, the yield can reach 3.16 g / L, and the ethanol tolerance is high, and can be applied in the wine making, condiment and food additive industries.

The application discloses a method for industrial production of sulindac. The method comprises the following steps: condensation reaction of compound 1 (5-fluoro-2-1-(4-methylthio benzyl) indene) and glyoxylic acid under catalysis of an organic base (benzyl trimethyl ammonium hydroxide) to generate compound 2, isomerization reaction of the compound 2 under hydrobromic acid-acetic acid solution to generate compound 3, which greatly improves reaction conversion rate and yield, reduces three waste problems, and finally obtains compound 4 (sulindac crude product) through oxidation of the obtained compound 3 by hydrogen peroxide, and high-purity sulindac is obtained through recrystallization of the crude product by isopropyl alcohol. The raw materials and reagents used in the preparation process of the sulindac are relatively cheap and low in cost, the whole preparation process is mild in reaction condition, simple and safe in operation, and convenient for industrial production.

Provided are plants, cells, tissues, and germplasm thereof comprising one or more targeted alterations of the genomic sequences of the MAM1 gene that encode for methylthioalkylmalate synthase, as well as meal made from such plant materials. Also provided are methods and compositions to make altered MAM1 gene variants; breeding methods and methods of identifying and selecting plant materials having the disclosed MAM1 variants.

The invention relates to the field of biological medicine, in particular to an aryloxy indole formic acid compound as well as a preparation method and application thereof. The general formula (I) of the aryloxy indole carboxylic acid compound is shown in the specification, wherein R1 is a Cl atom or a Br atom; r2 and R3 are two methylene groups connected to the same oxygen atom, or R2 is any one of a methyl group, a methoxy group, an isopropyl group, a methylthio group and a hydrogen atom, and R3 is any one of a halogen atom, a methyl group, a methoxy group, an isopropyl group, a propoxy group, an isopropoxy group, a butoxy group, an isobutoxy group, a cyclopropyl methoxy group, a benzyl group, a benzyloxy group and a hydrogen atom. As a thyroid hormone receptor agonist, the aryloxy indole formic acid compound has good THRbeta selectivity and THRbeta agonist activity, has the advantages of low toxicity and good biological safety, and has high practical value.

The present invention provides a 5'-methylthioadenosine phosphorylase mutant, the amino acid sequence of which is derived from a mutation of the sequence shown in SEQ ID No. 3 of the sequence table, wherein the mutation is selected from at least one of the following: H64A, P131D, W114N, L206S, E168Q, F217V, F217S, F217W, R219A, R219Q, R219F, V184A and V184T. The present invention also provides its application in the catalytic synthesis of 2'-fluoro-2'-deoxyadenosine. The mutant H64A / W114N / L206S of the present invention has an enzyme activity of 1.31 U / g, while the ApMTAP unmutated enzyme strain has an enzyme activity of 0.11 U / g, which is about 12 times higher than the enzyme activity, that is, the yield of 2'-fluoro-2'-deoxyadenosine has been greatly improved, and is suitable for the field of enzyme catalysis.

The invention discloses a novel 3-formyl-2-methyl-4-(methylthio) benzoate compound as shown in a general formula VI, wherein R is an ester group, carboxylic acid, amide or cyano group. The invention also provides a synthesis method of the intermediate shown in the formula VI and application of the intermediate in preparation of topramezone. The reaction selectivity for preparing topramezone by using the formula VI is higher, and the whole process route is more suitable for realizing industrial production;

Provided herein is (R)-7-chloro-2-((1r,4R)-4-(3-methoxyaetidin-1-yl)cyclohexyl)-2,4-dimethyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzo[d][1,3]dioxole-5-carboxamide, or a pharmaceutically acceptable salt thereof for use in methods of treating certain cancers having at least one BAP1 mutation.

The present invention discloses a preparation method of mesotrione, and the method steps are as follows: S1: Under the protection of an inert gas, 3-chloro-2-methylbenzenemethanethiol, phosphorus oxychloride, a composite catalyst and an organic solvent are mixed and reacted. After the reaction is completed, 2-chloro-3-methyl-4-methylthiophenylaldehyde is obtained through separation and vacuum distillation; 2-chloro-3-methyl-4-methylthiophenylaldehyde is mixed with sodium tungstate dihydrate and methanol, and hydrogen peroxide is added for reaction. After the reaction, 2-chloro-3-methyl-4-methylsulfonylbenzoic acid is obtained through filtration; S2: Preparation of 2-chloro-3-(2,2,2-trifluoroethoxy)methyl-4-methylsulfonylbenzoic acid; S3: 2-chloro-3-(2,2,2-trifluoroethoxy)methyl-4-methylsulfonylbenzoic acid is mixed and reacted with thionyl chloride and dichloroethane, and the reaction product is further reacted with 1,3-cyclohexanedione, triethylamine and samarium trichloride to prepare mesotrione. The present invention simplifies the preparation route of mesotrione, the preparation process is more green and safe, and the yield of mesotrione is higher.

This application relates to the field of pesticide intermediate synthesis technology, specifically disclosing a method for synthesizing 2-methylsulfonyl-4-trifluoromethylbenzoic acid. The method for synthesizing 2-methylsulfonyl-4-trifluoromethylbenzoic acid includes the following steps: 1) subjecting 2-nitro-4-trifluoromethylbenzonitrile to a methylsulfonation reaction to obtain 2-methylthio-4-trifluoromethylbenzonitrile; 2) subjecting the 2-methylthio-4-trifluoromethylbenzonitrile obtained in step 1) to an oxidation reaction under the action of a catalyst to obtain 2-methylsulfonyl-4-trifluoromethylbenzonitrile; 3) subjecting the 2-methylsulfonyl-4-trifluoromethylbenzonitrile obtained in step 2) to an alkaline hydrolysis reaction, followed by an acidification reaction to obtain 2-methylsulfonyl-4-trifluoromethylbenzoic acid. The synthesis method of this application has the advantages of high reaction efficiency, few process steps, and high yield.

A porphyrin compound for bioimaging and sonodynamic therapy, as well as its preparation method and application, has a chemical formula shown in Formula 2. The preparation method comprises the following steps: adding p-methylthiobenzaldehyde, a compound of Formula 1, and pyrrole to a reaction flask, evacuating the flask and introducing nitrogen gas, followed by adding anhydrous dichloromethane to obtain a reaction solution; bubbling nitrogen gas through the reaction solution, stirring at 25°C, adding boron trifluoride etherate, maintaining the temperature while continuing to stir, adding DDQ, continuing stirring, adding triethylamine, filtering, concentrating, and purifying to obtain the target product. This method features mild reaction conditions, a short reaction time, and simple operation. The resulting porphyrin compound exhibits excellent sonosensitivity and biocompatibility, can efficiently generate reactive oxygen species under ultrasound, and can produce excellent sonodynamic effects. The compound also exhibits fluorescence emission in the near-infrared region and can be excited by visible light, enabling confocal imaging to detect changes in cell morphology before and after, resulting in excellent bioimaging results. #imgabs0#

The invention relates to the technical field of biological catalysis, in particular to nitrilase and application thereof in methionine synthesis. The protein provided by the invention is selected from any one of the following items: (1) compared with an amino acid sequence as shown in SEQ ID NO.2, the protein comprises the following mutation sites: F188A and Q193Y; (2) a protein with nitrilase activity, which has at least more than 80% of identity with the protein in (1) and retains the mutation sites F188A and Q193Y; as a nitrilase mutant ScNLE-F188A / Q193Y, the protein can efficiently catalyze 2-amino-4-methylthio butyronitrile to generate 2-amino-4-methylthio butyric acid, the production efficiency reaches up to 73.9 kg methionine / kg DCW / h, and a potential efficient biocatalyst is provided for industrial production of methionine prepared by a biological enzyme method.

The invention discloses a synthesis method of a bithiophene polymer containing a methylthio group and application of the bithiophene polymer containing the methylthio group in a photoelectric device, and the synthesis method comprises the following steps: S1, mixing a monomer A (x mmol) containing thiophene, a monomer B (y mmol) containing the methylthio group and thiophene and a ligand in a nitrogen atmosphere, and then adding iron triacetylacetonate (0.067 M) dissolved in THF to obtain a solution; s2, slowly dropwise adding a toluene solution (1.6 M) of trimethylaluminum into the solution, and finally adding an oxidizing agent diethyl oxalate to obtain a mixed solution; s3, heating and stirring the mixed solution at 70 DEG C, dropwise adding methanol into the reaction solution after 22 hours to stop the reaction, and finally, repeatedly cleaning the reaction solution with various solvents to obtain a solid, namely the polytriarylamine bithiophene polymer containing the methylthio group, the invention relates to the technical field of bithiophene polymer synthesis, and due to the strong combination effect of the methylthio group and a metal interface, the polytriarylamine bithiophene polymer containing the methylthio group can be used for preparing the polytriarylamine bithiophene polymer containing the methylthio group. The polymer introduced with the methylthio substituent shows an excellent passivation effect, so that the energy conversion efficiency and the device stability are greatly improved.

Disclosed embodiments relate to a cleaning composition, a cleaning solvent, and a paint cleaning method. The cleaning composition according to one embodiment may include hexylene glycol, diethylene glycol monobutyl ether, and 4-(methylthio)butanol.

Provided herein are (R)-7-chloro-2-((1r, 4R)-4-(3-methoxyazetidin-1-yl) cyclohexyl)-2, 4-dimethyl-N-((6-methyl-4-(methylthio)-2-oxo-1, 2-dihydropyridin-3-yl) methyl) benzo [d] [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 3] dioxol-5-carboxamide or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt thereof.

The invention belongs to the technical field of polyphenylene sulfide composite materials, and particularly relates to a tracking-resistant polyphenylene sulfide composite material and a preparation method thereof. The anti-creepage tracking polyphenylene sulfide composite material is prepared from the following raw materials in parts by mass: 40 to 60 parts of linear polyphenylene sulfide, 10 to 15 parts of anti-creepage tracking agent, 10 to 15 parts of silane modified glass fiber, 3 to 5 parts of flexibilizer and 0.5 to 2 parts of lubricant, wherein the anti-creepage tracking agent is prepared by reacting aminophenyl POSS (Polyhedral Oligomeric Silsesquioxane) and a sulfenyl benzoyl chloride derivative according to a molar ratio of 1: (8.1 to 8.2); the thio-benzoyl chloride derivative is selected from one or a combination of more than two of 4-trifluoromethylthio-benzoyl chloride, 4-(methylthio) benzoyl chloride, 2-(isopropyl thio) benzoyl chloride and o-methylthio-benzoic acid acyl chloride. According to the invention, the anti-creepage tracking agent prepared by the reaction of the aminophenyl POSS and the sulfenyl benzoyl chloride derivative is used for replacing an inorganic anti-creepage tracking agent, so that the problem that the high-CTI polyphenylene sulfide composite material depends on high filling and thus the high and low temperature cycle resistance is reduced is solved.

The application relates to the field of organic synthesis, in particular to a method for synthesizing beta-trifluoromethylsulfinyl ketone derivatives by ring-opening of cyclopropanol. 3 C intermediates, and then adding a trifluoromethylating agent S-trifluoromethyl-4-methylthiobenzenesulfonate to obtain beta-trifluoromethylsulfinyl ketone derivatives. The application uses the simple, easy-to-prepare and stable S-trifluoromethyl-4-methylthiobenzenesulfonate as a trifluoromethylating agent, and the reaction condition is mild, and the synthesis method is simple and easy to operate.

The present invention provides an application of chitosan oligosaccharide aminomethylthiobutyramide derivatives in plant resistance to salt stress, belonging to the field of agricultural biotechnology. The derivatives are used to alleviate the oxidative damage of plants caused by salt stress, specifically including the following effects: (1) reducing the malondialdehyde content in plants; (2) increasing the activities of superoxide dismutase and peroxidase; and (3) promoting seed germination and seedling growth. The derivatives are formed by connecting the carboxyl group of methionine with the amino group of chitosan oligosaccharide through an amide bond, and the derivatives are 2-amino-4-methylthiobutyryl chitosan oligosaccharide, which is a methionine high-molecular chitosan oligosaccharide with a deacetylation degree of ≥90%. The polymerization degree of the methionine high-molecular chitosan oligosaccharide is 10-18. The present invention provides a methionine carrier for loading methionine into plants to improve the effect of plant resistance to salt stress.

The invention relates to a process for the preparation of 2-hydroxy-4-methylthiobutyric acid (HMTBA) or 2-hydroxy-4-methylselenobutyric acid (HMSeBA) by catalytic conversion of 2-hydroxy-4-methylthiobutyronitrile or 2-hydroxy-4-methylselenobutyronitrile, respectively, characterized in that the conversion is carried out in the presence of water and at least one weak acid and a catalyst comprising at least one of aluminium oxide, titanium dioxide and zirconium oxide.

The application relates to a preparation method of a mesotrione intermediate. S1, 3-chloro-2-methyl aniline, hydrochloric acid and pure water are placed in a reaction kettle, stirring, cooling, dropwise addition of a NaNO2 solution, after dropwise addition is completed, temperature control is carried out, CH3SNa aqueous solution is added, after dropwise addition is completed, slow temperature rising is carried out, and reaction is continuously carried out for 8 hours; extraction, water washing and distillation are sequentially carried out, and 1-chloro-2-methyl benzyl sulfide is obtained; S2, under the atmosphere of nitrogen, formylation reagent is added into a reaction kettle under the condition of 0-10 DEG C, a catalyst is dropwise added and stirring is carried out, 1-chloro-2-methyl benzyl sulfide is dropwise added, temperature rising is carried out, and 2-chloro-3-methyl-4-methylthio benzaldehyde is obtained through post-treatment; S3, under the atmosphere of nitrogen, methanol, 2-chloro-3-methyl-4-methylthio benzaldehyde and sodium tungstate dihydrate are added into a reaction kettle, hydrogen peroxide is dropwise added, the reaction temperature is controlled, and reaction is carried out, and the mesotrione intermediate is obtained through post-treatment.

This invention discloses a method for preparing sulindac. The method involves first performing an Arbuzov reaction and a Wittig-Horner reaction sequentially to obtain 6-fluoro-3-(p-methylthiobenzyl)-2-methyl-1H-indene. 6-fluoro-3-(p-methylthiobenzyl)-2-methyl-1H-indene undergoes a condensation dehydration reaction with glyoxylic acid, followed by double bond rearrangement under acidic conditions to obtain (Z)-5-fluoro-2-methyl-1-(p-methylthiobenzyl)-1H-indene-3-acetic acid. Finally, it undergoes a single oxidation reaction with an oxidant to obtain sulindac. The raw materials and excipients used in this invention are readily available, and the entire reaction route is short, the reaction conditions are mild, the operation is safe and simple, the yield is high, the purity is high, the production cost is low, and the emissions of waste are minimal, conforming to green industrial production standards. The total yield of the obtained sulindac product is over 75%, which is conducive to industrial production.