48 results about "Methylthio-ADP" patented technology

The invention relates to a preparation method of a metal halide perovskite-coated three-dimensional cobalt porphyrin-based COFs (Covalent Organic Frameworks) composite material, which comprises the following steps: S1, reacting an aldehyde precursor with an amine precursor in a first organic solvent, and after the reaction is finished, performing post-treatment to obtain a three-dimensional cobalt porphyrin-based COFs material; wherein the aldehyde precursor is 5 ', 5 '', 5'' '', 5'' ''''-(5, 10, 15, 20-tetrayl) tetra (([1, 1': 3 ', 1 ''-terphenyl]-4, 4''-diformyl))-21H, 23H-cobalt porphyrin (II), and the amine precursor is 4, 4'-diamino terphenyl and 2 ', 5'-bis ((methylthio) methyl)-[1, 1 ': 4', 1 ''-biphenyl]-4, 4''-diamine; s2, in a second organic solvent, enabling the three-dimensional cobalt porphyrin-based COFs material to react with lead bromide, and after the reaction is finished, performing post-treatment to obtain a PbBr2 (at) 3D Co-COFs material; and S3, in a third organic solvent, carrying out a reaction on the PbBr2 (at) 3D Co-COFs material and methylamine bromide, and after the reaction is finished, carrying out post-treatment to obtain the metal halide perovskite (at) three-dimensional cobalt porphyrin-based COFs composite material. The preparation method has the advantage that the photocatalytic activity and stability are improved.

The present application relates to a process for the preparation of pyroxasulfone comprising reacting 3-[(5-difluoromethoxy-1-methyl-3-trifluoromethylpyrazol-4-yl) methylthio]-4, 5-dihydro-5, 5-dimethylisoxazole with hydrogen peroxide in the presence of a metal catalyst wherein the solvent comprises at least one carbonate and water.

The utility model discloses a production system of 1-cyclopropyl-3-(2-methylthio-4-trifluoromethylphenyl) propyl-1, 3-diketone, which comprises an esterification unit and a condensation unit, and is characterized in that the esterification unit is connected with the condensation unit; the production system has the advantages that the production system is simple in connection structure and easy to implement, methyl 2-methylthio-4-trifluoromethyl benzoate is prepared from 2-methylthio-4-trifluoromethyl benzoic acid and the like through an esterification unit and then reacts with cyclopropyl ketone and other raw materials to prepare 1-cyclopropyl-3-(2-(methylthio)-4-(trifluoromethyl) phenyl) propyl-1, 3-diketone, and the production system has the advantages that the production system is simple in connection structure and easy to implement. The generation of three wastes is reduced, and the production cost is reduced; moreover, in the reaction process, the reaction temperature is not high, the reaction condition is mild, the yield is high, the production cost is low, the content of impurities in the product 1-cyclopropyl-3-(2-(methylthio)-4-(trifluoromethyl) phenyl) propyl-1, 3-diketone can be reduced, a high-quality reaction raw material is provided for subsequent industrial production of isoxaflutole, and the method is suitable for large-scale industrial production.

The application belongs to the field of microorganism and fermentation engineering, and provides a Candida magnoliae with high yield of 3-methylthiopropanol, and the preservation number is CGMCC NO. 23668. The Candida magnoliae can be used for producing 3-methylthiopropanol, the yield can reach 3.16 g / L, and the ethanol tolerance is high, and can be applied in the wine making, condiment and food additive industries.

The invention relates to the field of biological medicine, in particular to an aryloxy indole formic acid compound as well as a preparation method and application thereof. The general formula (I) of the aryloxy indole carboxylic acid compound is shown in the specification, wherein R1 is a Cl atom or a Br atom; r2 and R3 are two methylene groups connected to the same oxygen atom, or R2 is any one of a methyl group, a methoxy group, an isopropyl group, a methylthio group and a hydrogen atom, and R3 is any one of a halogen atom, a methyl group, a methoxy group, an isopropyl group, a propoxy group, an isopropoxy group, a butoxy group, an isobutoxy group, a cyclopropyl methoxy group, a benzyl group, a benzyloxy group and a hydrogen atom. As a thyroid hormone receptor agonist, the aryloxy indole formic acid compound has good THRbeta selectivity and THRbeta agonist activity, has the advantages of low toxicity and good biological safety, and has high practical value.

Provided herein is (R)-7-chloro-2-((1r,4R)-4-(3-methoxyaetidin-1-yl)cyclohexyl)-2,4-dimethyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzo[d][1,3]dioxole-5-carboxamide, or a pharmaceutically acceptable salt thereof for use in methods of treating certain cancers having at least one BAP1 mutation.

The application relates to the field of organic synthesis, in particular to a method for synthesizing beta-trifluoromethylsulfinyl ketone derivatives by ring-opening of cyclopropanol. 3 C intermediates, and then adding a trifluoromethylating agent S-trifluoromethyl-4-methylthiobenzenesulfonate to obtain beta-trifluoromethylsulfinyl ketone derivatives. The application uses the simple, easy-to-prepare and stable S-trifluoromethyl-4-methylthiobenzenesulfonate as a trifluoromethylating agent, and the reaction condition is mild, and the synthesis method is simple and easy to operate.

The invention relates to a process for the preparation of 2-hydroxy-4-methylthiobutyric acid (HMTBA) or 2-hydroxy-4-methylselenobutyric acid (HMSeBA) by catalytic conversion of 2-hydroxy-4-methylthiobutyronitrile or 2-hydroxy-4-methylselenobutyronitrile, respectively, characterized in that the conversion is carried out in the presence of water and at least one weak acid and a catalyst comprising at least one of aluminium oxide, titanium dioxide and zirconium oxide.

The application relates to a preparation method of a mesotrione intermediate. S1, 3-chloro-2-methyl aniline, hydrochloric acid and pure water are placed in a reaction kettle, stirring, cooling, dropwise addition of a NaNO2 solution, after dropwise addition is completed, temperature control is carried out, CH3SNa aqueous solution is added, after dropwise addition is completed, slow temperature rising is carried out, and reaction is continuously carried out for 8 hours; extraction, water washing and distillation are sequentially carried out, and 1-chloro-2-methyl benzyl sulfide is obtained; S2, under the atmosphere of nitrogen, formylation reagent is added into a reaction kettle under the condition of 0-10 DEG C, a catalyst is dropwise added and stirring is carried out, 1-chloro-2-methyl benzyl sulfide is dropwise added, temperature rising is carried out, and 2-chloro-3-methyl-4-methylthio benzaldehyde is obtained through post-treatment; S3, under the atmosphere of nitrogen, methanol, 2-chloro-3-methyl-4-methylthio benzaldehyde and sodium tungstate dihydrate are added into a reaction kettle, hydrogen peroxide is dropwise added, the reaction temperature is controlled, and reaction is carried out, and the mesotrione intermediate is obtained through post-treatment.

This invention discloses a method for preparing sulindac. The method involves first performing an Arbuzov reaction and a Wittig-Horner reaction sequentially to obtain 6-fluoro-3-(p-methylthiobenzyl)-2-methyl-1H-indene. 6-fluoro-3-(p-methylthiobenzyl)-2-methyl-1H-indene undergoes a condensation dehydration reaction with glyoxylic acid, followed by double bond rearrangement under acidic conditions to obtain (Z)-5-fluoro-2-methyl-1-(p-methylthiobenzyl)-1H-indene-3-acetic acid. Finally, it undergoes a single oxidation reaction with an oxidant to obtain sulindac. The raw materials and excipients used in this invention are readily available, and the entire reaction route is short, the reaction conditions are mild, the operation is safe and simple, the yield is high, the purity is high, the production cost is low, and the emissions of waste are minimal, conforming to green industrial production standards. The total yield of the obtained sulindac product is over 75%, which is conducive to industrial production.

The present disclosure relates to solid forms and salts of 7-chloro-2- (4- (3-methoxyazetidin-1-yl) cyclohexyl) -2, 4-dimethyl-N- ((6-methyl-4- (methylthio) -2-oxo-1, 2-dihydropyridin-3-yl) methyl) benzo [d] [1, 3] dioxole-5-carboxamide, which is useful as modulators the activity of histone methyl modifying enzymes. The present disclosure also provides pharmaceutically acceptable compositions comprising the crystalline form and methods of using said compositions in the treatment of various disorders.

The invention belongs to the field of microbial natural products, and particularly relates to a method for preparing an ultraviolet absorbent by utilizing Dermaccus nishiinomiyaensis and application of the ultraviolet absorbent. The invention relates to a method for separating and preparing an ultraviolet absorbent from pediococcus siuteri, wherein the ultraviolet absorbent is 3-hydroxyacetyl indole, 1-H-indole-3-pyrrole formaldehyde, perindoprine, (E)-3-methylthio acrylic acid, 1-acetyl-beta-carboline and dimethylisorolizine. The invention also relates to a method for preparing the ultraviolet absorbent by separating and preparing the ultraviolet absorbent from the pediococcus siuteri. Compared with the common ultraviolet absorbent benzophenone in the traditional sunscreen cosmetics, the sunscreen composition has stronger ultraviolet absorption capacity, and particularly, the perindoprine, the 1-acetyl-beta-carboline and the dimethylisoxazine have stronger absorption in the wave band of 320-400nm, so that the sunscreen composition can effectively prevent the skin from being tanned. Meanwhile, the ultraviolet absorbents come from coral mucus microorganisms, so that the ultraviolet absorbents have better environmental ecology and biological friendliness compared with the traditionally used chemically synthesized ultraviolet absorbents, and are safer and more environment-friendly to use.

The application discloses a synthesis method of 2-chloro-3-methyl-4-methylsulfonylbenzoic acid, which is obtained by one-step oxidation of 2-chloro-3-methyl-4-methylsulfanyl acetophenone with freshly prepared hypochlorite, and the freshly prepared hypochlorite is prepared by passing chlorine into a strong alkaline aqueous solution. It is found through a large number of tests that the freshly prepared sodium hypochlorite can simultaneously oxidize acetyl and methylthio, while the conventional industrial sodium hypochlorite can only oxidize acetyl and cannot oxidize methylthio. Therefore, compared with the prior art, the method disclosed by the application has fewer reaction steps, avoids the use of expensive sodium tungstate catalyst, greatly reduces the production cost, and in particular, the reaction yield of the application is obviously higher than the two-step reaction yield of less than 50% in the prior art.

The invention discloses a method for detecting related substances in N-methyl-1-methylthio-2-nitrovinylamine. The method comprises the following steps: (1) preparing a test solution; (2) preparing a contrast solution; (3) chromatographic detection, wherein chromatographic analysis conditions are as follows: octadecylsilane chemically bonded silica is adopted as a chromatographic column of a filler; carrying out gradient elution by using the mobile phase A and the mobile phase B; and the detection wavelength is 352 nm. According to the present invention, the efficient and accurate high performance liquid chromatography is adopted to perform determination, the impurity separation ability is significantly improved through the optimized gradient elution program and the design of the detection wavelength, the accurate quantification of the related substance is achieved by using the self-contrast method, and the method has advantages of strong specificity, high sensitivity, simple operation and good reproducibility.

The invention belongs to the technical field of synthesis, and particularly relates to a synthetic method of ethyl methylthioacetate, which comprises the following steps: taking ethyl chloroacetate and sodium methyl mercaptide as raw materials, taking water and ethyl acetate as solvents, and carrying out catalytic reaction, phase splitting, desolvation and rectification of a phase transfer catalyst to obtain the ethyl methylthioacetate. According to the method, the esterification decomposition influence of the raw materials in an alkaline water phase environment is solved, and meanwhile, the process cost and the process difficulty are greatly reduced.

The application belongs to the technical field of microorganisms, and provides a high-yield 3-methylthiopropanol Torulopsis pullulans, with a preservation number of CGMCC No.23667.The Torulopsis pullulans can be used for producing 3-methylthiopropanol, and the yield can reach 4.07 g / L, and the ethanol tolerance is high, so that the Torulopsis pullulans can be applied in the industries of brewing, tobacco fermentation, condiment and food additive.

The invention provides a composition for polishing a copper-interconnected ruthenium-based barrier layer, which comprises the following components in percentage by weight: 0.1-5wt% of silicon dioxide abrasive, 0.1-5wt% of organic solvent, 0.1-5wt% of organic solvent, 0.1-5wt% of organic solvent and the balance of water, 0.01 to 2 wt% of hydrogen peroxide; 0.01 to 3 wt% of an alcohol amine compound; 0.1 to 0.3 wt% of potassium ferrocyanide; 0.01 wt% to 0.3 wt% of 5-methylthio-1H-tetrazole; ammonia water and the balance of deionized water; the pH value of the composition is 9.0. According to the method, 5-methylthio-1H-tetrazole is introduced into a polishing system to serve as a copper inhibitor, potassium ferrocyanide and ethidene diamine are introduced to serve as ruthenium removal promoting components, the removal rate of ruthenium can be increased while excessive removal of copper and galvanic corrosion can be inhibited, copper protection and ruthenium removal are both considered, planarization treatment of wafers is achieved, and the quality of the wafers is improved. And the morphology of the dish-shaped pit and the corrosion pit is improved.

The invention relates to a method for constructing C-N coupling by an On-DNA (deoxyribonucleic acid) arylmethylthio compound and arylamine in a DNA (deoxyribonucleic acid) coding compound library. According to the method, an On-DNA aromatic methylthio compound is taken as a raw material and is subjected to C-N coupling in the presence of alkali, a ligand, a reducing agent and a palladium catalyst to obtain the On-DNA arylamine substituted methylthio compound. The method for the reaction of the On-DNA arylmethylthio compound and the arylamine, provided by the invention, can be carried out in a mixed phase of an organic solvent / water phase, post-treatment is simple, conditions are mild, a diversified DNA coding compound library can be obtained in a short time at a high yield, the types of C-N coupling substrates are expanded, and the method is suitable for synthesis of the DNA coding compound by a porous plate.

The application belongs to the technical field of medicine preparation, and particularly relates to a synthesis method of beta-trifluoromethylthio amide participated by silver trifluoromethylthiol, and the specific steps are as follows: in step 1, acrylamide, silver trifluoromethane thiol, acid and solvent are put into a thick-walled pressure-resistant tube for reaction, the reaction time is 8h, and the reaction temperature is 40-60 DEG C; in step 2, after the reaction is completed, dichloromethane is added to dilute the reaction solution, the organic solvent is removed by rotary evaporation, and the remaining product is separated by column chromatography to obtain beta-trifluoromethylthio saturated amide. By using the method in the application, the preparation of beta-trifluoromethylthio saturated amide can be realized in one step, the operation process is simple, the reaction efficiency is effectively improved, in addition, the reaction temperature is only 40-60 DEG C, and the method has the advantages of low reaction energy consumption, low overall production cost and high degree of technical environmental friendliness.

The application discloses an improved preparation and refining method of 2-hydroxy-4-methylthio-butanoic acid isopropyl ester, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: raw material pretreatment, esterification reaction and post-treatment. In the esterification reaction, a raw material mixture and dichloromethane are added into a four-necked flask with a condensing device, the temperature of the four-necked flask is controlled to 85-90 DEG C, stirring is carried out, then a solid acid catalyst and 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride are added, stirring is carried out for 6-7 h, and a reaction solution is obtained. The preparation method of the solid acid catalyst comprises the following steps: preparing a carrier, primary impregnation modification and secondary impregnation modification. The application can improve the purity of the prepared 2-hydroxy-4-methylthio-butanoic acid isopropyl ester, does not cause corrosion of production equipment, and uses a catalyst with high catalytic activity and high thermal stability, which is not prone to blockage in use and can be used repeatedly.

The invention belongs to the field of food additive essence. The invention discloses pot gas essence and a preparation method and application thereof, and the pot gas essence comprises the following components: caprylic / capric triglyceride, benzyl alcohol, black pepper oil, 2-acetylpyrazine, methylcyclopentenolone, ethyl maltol, 4-hydroxy-2, 5-dimethyl-3 (2H) furanone, 2-tridecanone, acetic acid, 2, 5-dimethylpyrazine, furfuryl mercaptan, 1, 3, 4-trimethyl-1, 3-pentanediol, 1, 3, 4-trimethyl-1, 3-pentanediol, 1, 3, 4-trimethyl-1, 3-pentanediol, 1, 3, 4-trimethyl-1, 3-pentanediol, 1, 3, 4-trimethyl-1, 3-pentanediol, 1, 3, 4-trimethyl-1, 3- The invention relates to an anti-rust oil which is prepared from 1, 8-cineole, 3-(methylthio) propionaldehyde, oleic acid, phenethyl alcohol, sesame oil, 2-decenal, 2, 4-undecadienal, phenylacetaldehyde, 3-(methylthio) butyraldehyde, 3-(methylthio) propanol, bis (2-methyl-3-furyl) disulfide, 2-methyl-3-mercaptofuran and 2, 3-pentanedione. The pot gas essence can simulate real pot gas flavor, and prepared food is good in temperature resistance, high in verisimilitude, lasting and stable in flavor, small in dosage and low in cost and has high application value.

The invention discloses a method and a system for continuously preparing 2-(methylthio) phenylboronic acid by a microchannel reactor, and belongs to the technical field of synthesis and preparation of 2-(methylthio) phenylboronic acid. According to the technical scheme, the preparation method comprises the following steps: S1, preparing raw materials: respectively dissolving reactants including 2-methylthio bromobenzene, boric acid ester, hydrochloric acid and n-butyllithium into a solvent, and respectively preparing a 2-methylthio bromobenzene solution, a boric acid ester solution, an acid solution and an n-butyllithium solution; s2, micro-channel reaction: respectively conveying the 2-methylthio bromobenzene solution, the n-butyllithium solution, the borate solution and the acid solution prepared in the step S1 into a micro-channel reactor through a flow rate pump, and carrying out the micro-channel reaction on the 2-methylthio bromobenzene solution, the n-butyllithium solution, the borate solution and the acid solution. And S3, separation and purification: carrying out separation and purification on the reaction liquid obtained in S2 to obtain the required product 2-methylthio phenylboronic acid. According to the invention, simultaneous three-step cascade reaction is carried out in the microchannel reactor to synthesize 2-methylthio phenylboronic acid. The reaction efficiency is improved; and the production energy consumption is reduced.

A method for synthesizing a stable isotope-labeled toltrazuril-D3 belongs to the field of organic synthesis technology. This method uses methylamine hydrochloride-D3 as the stable isotope labeling source, reacting it with p-trifluoromethylthiophenol and 1-chloro-2-methyl-5-nitrobenzene as starting materials, undergoing sequential condensation and reduction to obtain an aminodiphenyl ether intermediate. Simultaneously, methylamine hydrochloride-D3 reacts with sodium cyanate to generate methylurea-D3, which then reacts with carbonyl diimidazole to obtain an activated intermediate. Finally, the aminodiphenyl ether intermediate condenses with the activated intermediate, followed by base-catalyzed cyclization to obtain the target product, toltrazuril-D3. This invention features a rationally designed synthetic route, readily available raw materials, mild reaction conditions, simple operation, and easy product separation and purification. The obtained product achieves a chemical purity and isotope abundance of over 99%.

This application provides a tubing thread sealant for shallow coalbed methane wells, its preparation method, and its application, belonging to the field of oilfield development. The tubing thread sealant comprises: component A, component B, and component C; wherein, by weight, component A includes the following chemical components: 41-61 parts of polymer matrix, 15-23 parts of 5-methylthio-7-fluoro-1H-indene, and 23-37 parts of excipients; component B includes the following chemical components by weight: 80-90 parts of epoxy curing agent and 10-25 parts of epoxy curing accelerator; and component C is an additive. In component A, a polymer matrix is ​​used as the matrix. By introducing molecularly designed active substances containing fluorine and sulfur elements, such as 5-methylthio-7-fluoro-1H-indene, the material combines the weather resistance and toughness of rubber while maintaining stable performance at high temperatures, making it less prone to deformation or failure.

The application relates to the technical field of organic synthesis, and particularly discloses a synthesis method and application of 2-chloro-4-methoxy-6-methylthio-1,3,5-triazine. The synthesis method of 2-chloro-4-methoxy-6-methylthio-1,3,5-triazine comprises the following steps: 2,4,6-trichloro-1,3,5-triazine is added into methanol, sodium bicarbonate is added, and stirring and mixing are carried out to obtain a mixed solution; methyl mercaptan is added into the mixed solution at -10-0 DEG C, and stirring reaction is carried out at 10-30 DEG C for 2-3 hours to obtain a reaction solution; ice water is added into the reaction solution, standing is carried out, solid is collected through filtration, and drying is carried out to obtain 2-chloro-4-methoxy-6-methylthio-1,3,5-triazine. The 2-chloro-4-methoxy-6-methylthio-1,3,5-triazine disclosed by the application can be used for synthesizing sulfonylurea herbicides, and has the characteristics of easy degradation, low toxicity, high activity and low cost.

The application discloses coffee essence, atomized liquid and electronic atomization device, and belongs to the field of electronic atomizers. The coffee essence comprises 2-acetylpyrrole, vanillin, methylcyclopentenolone, maltol, furfuryl acetate, guaiacol, isopentyl alcohol propylene glycol solution, furfuryl mercaptan, 2-ethyl-3,5-dimethylpyrazine, isovaleric acid propylene glycol solution, 2,3,5-trimethylpyrazine, isobutyraldehyde, 2-methyl-3-(methylthio)pyrazine, isoamyl aldehyde, trigonellin, 4-hydroxy-2,5-dimethyl-3(2H)-furanone, 5-methylfurfural, dimethyl sulfide, 2-acetylfuran, 5-hydroxyethyl-4-methylthiazole, 2-acetylpyrazine, 4-ethylguaiacol, acetic acid, propionic acid, acetaldehyde propylene glycol solution, 4-methyl-5-(2-acetyloxyethyl)-thiazole and propylene glycol. The coffee essence has good stability, good compatibility and can accurately restore the real coffee roasting aroma.

Provided herein, in part, are compounds of Formula I and Formula II and pharmaceutically acceptable salts thereof. Such compounds can inhibit MEK activity, thereby affecting biological functions, and may be useful for treating a subject having a MEK-associated tumor. Also provided herein are solid forms of 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione. Also provided are pharmaceutical compositions and medicaments comprising compounds of any of the formulas described herein and pharmaceutically acceptable salts thereof, which may be useful for treating a subject having a MEK-associated tumor, alone or in combination with additional anticancer therapies.Also provided herein are methods for preparing compounds, pharmaceutically acceptable salts, and pharmaceutical compositions according to any of the formulas described herein and pharmaceutically acceptable salts thereof, as well as methods of using the foregoing. This summary is provided to introduce a selection of concepts in a simplified form that are further described in the detailed description.

The application discloses a preparation method of a lung cancer treatment drug, adagrasib, which comprises the following steps: in step 1, 1-chloro-8-iodonaphthalene is subjected to C-N coupling reaction with 4-chloro-2-(methylthio)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine to obtain 4-chloro-7-(8-chloronaphthalen-1-yl)-2-(methylthio)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine; in step 2, the product in step 1 is subjected to oxidation reaction to obtain 4-chloro-7-(8-chloronaphthalen-1-yl)-2-(methylsulfinyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine; and in step 3, the product in step 2 is subjected to docking reaction with [(2S)-1-methylpyrrolidin-2-yl]methanol, and then subjected to C-N coupling reaction with (S)-2-(1-(2-fluorovinylcarbonyl)piperazin-2-yl)acetonitrile to obtain adagrasib. The synthesis method of the adagrasib has the advantages of a short route, easy customization of starting materials, safe and simple operation, low cost and environmental friendliness, and the like, as compared with the prior art.

This invention discloses the application of 2-[(3-methylphenyl)methylthio]-3,4-dihydropyrimidin-4-one in the preparation of drugs for the prevention and / or treatment of Candida albicans, belonging to the field of biomedical technology. The compound 2-[(3-methylphenyl)methylthio]-3,4-dihydropyrimidin-4-one is a compound targeting copper homeostasis-related molecules in Candida albicans. At a concentration of 100 μM, it significantly inhibits Candida albicans hyphal formation, and the inhibitory effect is further enhanced at a concentration of 200 μM. Using a large wax moth infection model, it was confirmed that this compound can reduce the virulence of Candida albicans in a dose-dependent manner, and the survival rate of the large wax moth in the 2 mg / kg treatment group was approximately 80%. Simultaneously, this compound can effectively inhibit the colonization of Candida albicans in the host, with a significantly lower bacterial load 48 hours after treatment compared to the control group. This invention provides a new drug candidate for the treatment of Candida albicans infection and has good application prospects.

The invention discloses a method for preparing 2, 2-dimethylthiopropane, which comprises the following steps: respectively conveying feed liquids containing sodium methyl mercaptide, acetone and inorganic acid into a microchannel reactor at the same time, quickly mixing to form a multiphase Taylor flow reaction system, and then reacting in a microchannel under high temperature and high pressure conditions; and after the reaction is finished, rapidly cooling the material, enabling the material to enter a continuous gas-liquid-liquid separation system, and washing, drying and rectifying an organic phase obtained by separation to obtain high-purity 2, 2-dimethylthio propane. The method effectively solves the problem that the foul smell of methyl mercaptan escapes in the prior art, remarkably improves the operation environment, and realizes the effects of high raw material conversion rate and short reaction time through high-temperature and high-pressure continuous reaction in the microchannel. In addition, the micro-reaction process has the characteristics of simplicity and convenience in operation, high reaction efficiency and intrinsic safety.