300 results about "Methylthio-ADP" patented technology

The invention relates to a polymerisable monomer applied to a display panel. The polymerisable monomer is expressed by a chemical formula above, wherein, m is not less than 0, 'Z' is selected from oxygen atom, sulfur atom, carbonyl, carboxyl, methoxyl, methylthio, sulfenyl, ethylene carbonyl, carboxyethenyl, difluoromethoxyl, difluoromethylthio, ethyleneyl, difluoroethyl, tetrafluoroethyl, ethenyl, difluoroethenyl and ethinyl or single bonds; 'X1' and 'X2' are independently selected from oxygen atom, sulfur atom, methoxyl, carbonyl, carboxyl, amine formacyl, methylthio, ethylene carbonyl and carboxyethenyl or single bond; 'Sp1' and 'Sp2' are independently spacer groups or single bonds; and 'P1' and 'P2' are independently polymerisable groups. The invention further relates to a liquid crystal material which contains liquid crystal molecules and the polymerisable monomer.

The invention discloses a method for preparing methionine and recovering a by-product-carbon dioxide. The method comprises the steps that a methionine salt and carbonate mixed solution obtained by hydrolyzing methylmercapto-ethyl hydantoin with alkali is filtered through a microporous membrane, and then filtrate is delivered to a bipolar membrane electrodialysis system to be subjected to electrodialysis treatment, so that acid liquor A and alkali liquor A are obtained; the alkali liquor A is treated continuously and cyclically, and the acid liquor A is subjected to gas-liquid separation, so that gaseous carbon dioxide and acid liquor B are obtained; the acid liquor B is delivered back into the bipolar membrane electrodialysis system to be subjected to cyclic treatment till the pH value of the acid liquor B is 3.8-4.5, the reaction is completed, a methionine solution is prepared, and the methionine is prepared through concentration and crystallization of the methionine solution; the gaseous carbon dioxide is introduced into an absorption cell, and carbon dioxide on the upper portion of the absorption cell absorbs mother liquor, is subjected to membrane distillation and concentration and then is circulated back to the absorption cell; carbonate crystals are grown at the bottom of the absorption cell and guided out from the bottom of the absorption cell; and carbonate is recovered through solid-liquid separation. According to the method for preparing the methionine and recovering the by-product-carbon dioxide, the gaseous carbon dioxide is recycled, so that carbon emission is reduced, and energy resources are saved through the membrane distillation technique.

The invention relates to an amino acid-fluorophore compound and application of the compound, wherein the general structural formula of the amino acid-fluorophore compound is (I), (II), (III), and (IV) or a free form thereof, wherein R1 is selected from various amino acid side chains, preferably methyl, propyl, 2-methylthio ethyl, benzyl, phenylethyl, 2-cyclohexyl ethyl, 4-isopropyl phenyl and 4-dimethyl amino phenyl; R2 is selected from various fluorophores, preferably 7-hydroxyl coumarin, naphthalimide fluorophores, Nile red series and Cy fluorophores; and X is C or N. Fluorescent probe molecules can be used for detecting the activity (enzyme level and cell level) of aminopeptidase N, can be used as a probe tool for detecting the tissue distribution of aminopeptidase N and tumor tissue imaging, and can be used as a diagnosis tool for various diseases due to abnormal expression of aminopeptidase N. In addition, the preparation method of the compound has the advantages of mild reaction conditions, easily-accessible and cheap raw materials and simplicity in operation and after-treatment.

Compounds represented by the general formula:[wherein R1 represents methoxy, ethyl, methylthio, etc., R2, R3 and R4 each represent hydrogen, a halogen, etc., R5 and R6 each represent —X5—X6—X7 (wherein X5 represents a single bond or —CO—, X6 represents a single bond, —NR3a, etc. and X7 and R3a each represent hydrogen, C1-10 alkyl, etc.), and Ar represents phenyl, pyridyl, etc.], salts thereof and hydrates of the foregoing.

The invention provides a synthetic method for sulforaphane and belongs to the field of drug synthesis. The method comprises the following steps that: after amino in 4-amino-1-butanol is protected by Boc groups, hydroxy in 4-amino-1-butanol is changed into methanesulfonyl ester by methanesulfonyl chloride, and then the resultant reacts with sodium methyl mercaptide to produce 4-methylthio butyl-1-tert-butoxycarbonylamide; Boc protective groups are removed under acidic condition to obtain 4-methylthio-1-butylamine; 4-methylthio-1-butylamine reacts with carbon disulfide for one hour in the presence of triethylamine and p-toluenesulfonyl chloride is added for treatment for half an hour to produce 4-methylthio butyl-1-isothiocyanate; and at last 4-methylthio butyl-1-isothiocyanate is oxidized by m-CPBA to produce sulforaphane. According to the invention, complex hydrazinolysis of phthalimide in aftertreatment is avoided and toxic thiophosgene is not needed in the preparation of isothiocyanate; overall yield of sulforaphane is 64%, substantially higher than the overall yield of 8% reported in literature; the whole preparation process is simple and time-saving and is suitable for large scale production.

The invention relates to a novel compound 6-N-(2-(methylthio)ethyl)-2-((3,3,3-trifluoropropyl)sulfo)-9H-purine and a preparation method for the novel compound and further provides application of the novel compound as an intermediate in synthesis of cangrelor directed at the limitation of conventional synthetic methods for cangrelor. The compound is used as the intermediate for synthesis of cangrelor; and such a route has the advantages of wide sources of raw materials, mild reaction conditions, simple after-treatment, environment friendliness and improved product yield and provides a novel synthetic method for laboratory and industrialization production of cangrelor.

The invention relates to a medicine producing field, specifically, to an improved producing method of antibacterial medicine nifuratel. The method makes use of thiourea as initial material to produce nifuratel. The improvement is that it is no longer to use methyl mercaptan or methomyl in the known method while producing the intermediate 2-(methylthiomethyl)hydropropane. Furthermore, the invention is no longer to use metal natrium in the known method when the 3-methylthio-2-hydroxy-propylhydrazine and diethyl carbonate are heated to produce N-amido-5-methylthiomethyl-2-oxazolidone in the existance of alkali. All of the improvements largely improve the preparation of the nifuratel, especially for the production condition in a large scale, reduce the environment pollution and benefit to ensure the production safety.

The present invention discloses a combination of macrolides insecticide and insecticide of Sufluoxime, wherein the macrolides insecticide is spinosad, avermectin, the derivative thereof, etc., and the Sufluoxime is 1-(3-fluoro-4-chlorophenyl)-2-methylthioethanone-O-(2-hydroxymethyl-3-methyl) aether. The various surfactants and additives such as carrier, thickening agent, stabilizing agent, antifreeze agent, antifoaming agent, adhesive and the like are added to prepare an insecticidal composition in dosage forms of missible oil, aqueous emulsion, microemulsion, suspending agent, granular formulation, water dispersible powder or dispersible granula, etc. The insecticidal composition has characteristics of evident synergism, resistance delay, widening the spectrum of insect disinfestation, etc., and has disinfestation effect to the destructive insect in the disinfestation range of two normal insecticides.

A reactive rectification column suitable for the production of 2-hydroxy-4-methylmercaptobutyric acid and / or methionine contains a weir having a height of 100 mm or more.

The invention relates to a synthetic method for 5-chloro-6-(2-iminopyrrolidinyl-1-yl)methyl-2,4-(1H,3H)pyrimidinedione hydrochloride. The synthetic method comprises the following steps: with S-methylisothiourea sulfate as a starting raw material, subjecting S-methylisothiourea sulfate and ethyl chloroacetoacetate to a cyclization reaction under an alkaline condition so as to obtain 6-(chloromethyl)-2-(methylthio)pyrimidine-4(3H)-one; carrying out a chlorination reaction on a pyrimidine ring so as to obtain 5-chloro-6-(chloromethyl)-2-(methylthio)pyrimidine-4(3H)-one; then carrying out a hydrolysis reaction under an acidic condition so as to obtain 5-chloro-6-(chloromethyl)pyrimidine-2,4-(1H,3H)-dione; and reacting 5-chloro-6-(chloromethyl)pyrimidine-2,4-(1H,3H)-dione with 2-iminopyrrolidinyl hydrochloride so as to obtain 5-chloro-6-(2-iminopyrrolidinyl-1-yl)methyl-2,4-(1H,3H)pyrimidinedione hydrochloride, i.e., a finished product of hydrochloride. The synthetic method has the advantages of simple operation, a stable intermediate, easy availability, high yield and easy realization of industrial production.

The invention discloses pear essence. The pear essence mainly comprises the following components: 95-97.5% of ethyl alcohol, 0.5-1% of ethyl butyrate, 0.2-0.7% of ethyl acetate, 0.2-0.7% of ethyl propionate, 0.1-0.5% of ethyl-2-methyl butyrate, 0.1-0.5% of butyl acetate, 0.1-0.6% of isoamyl acetate, 0.1-0.5% of ethyl hexanoate, 0.1-0.5% of hexenyl acetate and 0.1-0.7% of methyl 3-methylthiopropionate. Accordingly, the invention also discloses a preparation method of the pear essence. The preparation method of the pear essence comprises the steps of sequentially adding main ingredients of the pear essence in proportion, uniformly mixing and ripening, thus the pear essence product is obtained. By adopting the preparation method of the pear essence, the pear essence has strong fruit juice taste and sufficient characteristic fragrance and can reserve natural flavour of natural pear juice; the pear essence belongs to a beverage product, and reality, smoothness and fragrance of beverage taste can be obviously enhanced.

The invention aims at the chemical engineering field, and relates to a method for using crude hydrocyanic acid gas for preparing 2-hydroxy-4-methylmercapto-butyronitrile. Based on the Andrussow method composition principle, the method takes methane, ammonia gas and oxygen gas as raw material to obtain hydrocyanic acid mixed gas I through preparation; the hydrocyanic acid mixed gas I is subjected to deamination treatment to obtain hydrocyanic acid mixed gas II; under the alkaline catalytic action, the hydrocyanic acid mixed gas II is fully reacted with methylmercapto-propionaldehyde to obtain the 2-hydroxy-4-methylmercapto-butyronitrile. The raw material without rectification and purification is adopted for the method and is low in price and easy to get, and the prepared 2-hydroxy-4-methylmercapto-butyronitrile is high in yield and purity. Moreover, an obtained 2-hydroxy-4-methylmercapto-butyronitrilereaction system not purified and separated is stable in property, capable of being stored for a long time and convenient to use in production of down-stream products.

The invention relates to a method for synthesizing a high-efficiency photoinitiator 2-methyl-1-[4-(methylthio)phenyl]-2-(4-morpholinyl)-1-propanon. In the method, 2-methyl-1-[4-(chloro)phenyl]-2-(4-morpholinyl)-1-propanon serving as a raw material is reacted with sodium methyl mercaptide in an organic water two phase solution system taking quaternary ammonium salt as a catalyst to generate the target product.

The present invention discloses a clean method for preparing a D,L-methionine comprising the steps of: preparing a potassium cyanide solution using a crystallized mother solution containing potassium carbonate as an absorbing liquid to absorb hydrocyanic acid, then reacting the potassium cyanide solution with 3-methylthio propionaldehyde and an ammonium bicarbonate solution at 50-150° C. for 3-15 minutes so as to obtain a 5-(β-methylthioethyl)glycolyurea solution, then bring the 5-(β-methylthioethyl)glycolyurea solution to a temperature of 140-220° C. and subjecting to a saponification reaction for 2-5 minutes, after the completion of the saponification, reducing the temperature to 0-40° C., extracting with an organic solvent, neutralising the water phase with CO2 and crystallizing, then filtering, washing, and drying to obtain an acceptable D,L-methionine product; bring the crystallized D,L-methionine mother solution from filtration to a temperature to 110-160° C. to remove CO2, which are all then circulated and used as a hydrocyanic acid-absorbing liquid. The process route of the present invention is a route suitable for a continuous and clean production, substantially without producing waste water and waste gas.

The invention discloses a fishy flavor agent for a feed and a preparation method of the fishy flavor agent. The fishy flavor agent contains the following perfume materials in percentage by weight: 0.5-2% of glycine betaine, 1-3% of trimethylamine, 0.1-2% of 2-methyl-3-sulfydrylfuran, 0.1-1% of pyrrolidine, 0.1-1% of piperidine, 0.1-2% of phenylethylamine, 0.01-1% of 2-acetylpyridine, 0.1-1% of furanone, 1-3% of ethyl maltol, 1-3% of 2-acetylpyrazine, 1-3% of 2,3,5-trimethylpyrazine, 0.01-2% of 3-methylthiopropanal, 30-70% of fishy smell reactants and 10-60% of glycerol triacetate. The fishy flavor agent is prepared by carrying out enzymolysis on animal wastes, then adding reducing sugars to carry out Maillard reaction, and then, adding artificial synthetic essence to blend. The fishy flavor agent has the advantages that the animal wastes are reasonably utilized, the preparation process is simple, and the product is strong in fragrance, stable and easy to store.

The invention discloses a compound containing trifluoromethylthio group and a preparation method thereof. The invention discloses a compound 7, compound 9 or compound 11 containing trifluoromethylthio group. The invention provides a preparation method of the compound 7, 9 or 11, which comprises the following steps: in an organic solvent, carrying out substitution reaction on a compound 1 and a beta-eleostearate compound 6 in the presence of an alkali to obtain the compound 7; in an organic solvent, carrying out substitution reaction on the compound 1 and an aldehyde or ketone compound 8 in the presence of a catalyst and an additive to obtain the compound 9; and under the gas protection, carrying out substitution reaction on the compound 1, cuprous iodide and an alkyne compound 10 in an organic solvent in the presence of an alkali to obtain the compound 11. The preparation method of the compound 7, 9 or 11containing trifluoromethylthio group has the advantages of mild reaction conditions, high conversion rate, high yield and low production cost, and is suitable for industrial production.

The invention relates to a method for preparing avanafil. The method is characterized by comprising the step of enabling 4-(3-chloro-4-methoxybenzylamino)-5-ethoxycarbonyl-2-methylthiopyrimidine to be subjected to hydrolysis, condensation, oxidation and substitution reaction sequentially, thereby preparing avanafil. The method has the advantages of being simple and convenient in operation, easy in product quality control, high in reaction yield, high in product purity, low in cost and applicable to industrial production and the like.

The invention concerns a method for preparing acrolein from glycerol or glycerine, wherein dehydration of the glycerol or glycerine is achieved in the presence of a catalyst based on zirconium oxide and which active phase consists in at leasta) a silicon oxide, a zirconium oxide and at least one metal M oxide, said metal being selected from tungsten, cerium, manganese, niobium, tantalum, vanadium and titanium,b) a titanium oxide, a zirconium oxide and at least one metal M oxide, said metal being selected from tungsten, cerium, manganese, niobium, tantalum, vanadium and silicon.This method can be used for making 3-(methylthio)propionic aldehyde MMP, 2-hydroxy-4-,methylthiobutyronitrile HMTBN, methionine and its analogs.

The invention belongs to the technical field of synthesis of organic compounds, and relates to a synthesis method of silver(I) trifluoromethanethiolate. According to the synthesis method of silver(I) trifluoromethanethiolate (CAS number: 811-68-7) in the invention, silver fluoride is used as a raw material and trifluoromethylthioester is used as a trifluoromethylthio source so as to synthesize silver(I) trifluoromethanethiolate. According to the method, trifluoromethylthioester is used as the trifluoromethylthio source and reacts with the silver fluoride in a solvent to generate silver(I) trifluoromethanethiolate, and a finished silver(I) trifluoromethanethiolate product is obtained after separation and purification. According to the synthesis method of silver(I) trifluoromethanethiolate, raw materials are easy to obtain, reaction reagents are easy to prepare and low in price, the synthesis cost of silver(I) trifluoromethanethiolate is remarkably reduced, synthesis conditions are mild, operation is easy, convenient and safe, industrial production is facilitated, the utilization rate of silver atoms is high, and environmental protection is realized.

The invention relates to high-yield 3-Methionol saccharomyces cerevisiae engineering bacteria and a preparation method and application thereof, and belongs to the technical field of biological preparation of food flavors. According to the high-yield 3-Methionol saccharomyces cerevisiae engineering bacteria and the preparation method and application thereof, the engineering bacteria is designed and constructed through the coupling excessive expression of an aminotransferase gene (ARO9) and a decarboxylase gene (ARO10) and the knock-out of a methylthio lyase gene (CY3) in the anabolic pathway of Methionol by taking Saccharomyces cerevisiae S288c as an original strain; the expression of two key enzyme genes in a main synthetic pathway is enhanced, and the expression of the CY3 gene in a side reaction pathway is reduced or eliminated; the bred engineering bacteria (converter) is subjected to multiple-time passage and stable in inheritance, so that the metabolic network and metabolic pathway of the biological synthesis of the Methionol are optimized, and the metabolic flux and yield of the Methionol are obviously increased; a Methionol flavor prepared by fermenting and converting the engineering bacteria is single in structure and chirality and high in fragrance quality.

The invention a preparation method of 2-methyl-2-(4-morpholinyl)-1-[4-(methylthio)phenyl]-1-acetone. The 2-methyl-2-(4-morpholinyl)-1-[4-(methylthio)phenyl]-1-acetone prepared by the method provided by the invention is an efficient radical ultraviolet initialtor and is suitable for the single-function or multifunctional monomer ultraviolet curing system and an acrylate prepolymer. The compound can be used alone or used together with photo initiators (ITX and 184). As the compound has efficient ultraviolet absorption property, the compound is especially suitable for being used in the formulas of oil and colored paint such as offset ink, silk screen printing ink and printing plate-making photoresist. The method has the advantages of simple processing equipment, easiness for operation and low cost; the prepared compound has high purity; and the product purity reaches more than 99%.

The invention relates to a chiral catalytic synthesis method of thiamphenicol which is a chloramphenicol broad-spectrum antibiotic. Thioanisole serves as an initating raw material, acylation and bromo are achieved, nitrogen iridine containing substituent groups is synthetized, and a qualified product which meets the requirement of drug administration is synthetized through chiral catalytic reduction, oxidizing reaction, acidification loop opening, deprotection and acylation reaction. The chiral catalytic reduction includes that under the action of a catalyst trans-RuC12[(R)-xylbinap][(S)-DPEN], [1-substituent group nitrogen iridine-2-group] [4-(methylthio group) phenyl group] ketone is subjected to hydrogenation reduction to obtain [1-substituent group nitrogen iridine-2-group] [4-(methylthio group) phenyl group] ketone with a high ee value and a high de value. D-methylsulfonylphenyl serine ethyl ester used in industrial production serves as a raw material to synthetize the thiamphenicol, the D-methylsulfonylphenyl serine ethyl ester is obtained through chemical chiral resolution by using a racemic compound, and the other half of the raw material is wasted. According to the unsymmetrical chiral catalytic dynamic reduction method, waste of the other half of the raw material is avoided, the utilization rate of a material is improved, and the production cost is reduced.

The invention relates to a method for preparing acrolein from glycerol or glycerine, comprising dehydrating glycerol or glycerine in the presence of a catalyst consisting of at least a) a mixed oxide of zirconium and at least one metal, said metal being selected from niobium, tantalum and vanadium, b) a zirconium oxide and at least one metal oxide, the metal being selected from niobium, tantalum and vanadium, c) a silicon oxide and a mixed oxide of zirconium and at least one metal, the metal being selected from tungsten, cerium, manganese, niobium, tantalum, titanium, vanadium and silicon, d) a silicon oxide and a mixed oxide of zirconium and at least one metal, the metal being selected from tungsten, cerium, manganese, niobium, tantalum, vanadium and titanium, e) a titanium oxide and a mixed oxide of zirconium and at least one metal, said metal being selected from tungsten, cerium, manganese, niobium, tantalum, titanium, vanadium and silicon, f) a titanium oxide and a mixed oxide or zirconium and at least one metal, said metal being selected from tungsten, cerium, manganese, niobium, tantalum, titanium, vanadium and silicon. The method can be used for producing -3-(methylthio)propionic (MMP) aldehyde, 2-hydroxy-4-methylthiobutyronitrile (HMTBN), methionine and analogues thereof from acrolein.

The invention relates to the technical field of fine chemical engineering, and discloses a method for preparing asymmetric disulfide. The preparation method comprises the following specific steps: taking 3-methylthio-N-phenylpropionamide and diphenyl disulfide as raw materials, taking N-fluorobisbenzenesulfonamide as an additive, and preferably carrying out a reaction in an acetonitrile solvent under a heating condition so as to obtain a target product, namely the symmetric disulfide N-phenyl-3-(phenyldithioalkyl)propionamide. The method is simple and convenient to operate and mild in reaction, 3-methylthio-N-phenylpropionamide and symmetric diphenyl disulfide are used as reaction raw materials, the asymmetric disulfide product is efficiently synthesized in one step, the use of a thiol rawmaterial with unpleasant smell or a transition metal catalyst is avoided, and the method has a potential application value.

This invention relates to an organic iodine complex, in which iodine serves as coordination center and functional group-containing organics serve as chelating reagent. The functional groups can be amino and / or hydroxyl and / or carboxyl, and the representatives of hydroxyl- and carboxyl-containing organics are 2-hydroxy-4-methylthiobutanoic acid and 2-hydroxypropanoic acid, respectively. This invention also relates to a combination of organic iodine complex and its application in pharmacy. The combination comprises 0.3~40% organic iodine complex as active ingredient and one or more ingredients chosen from the following ones: natural aminoacyl iodine, solvent, surfactant, food additives, food and synthesized drugs. This combination can be used in preparation of drug against AIDS, white spot syndrome virus in penaeid shrimp, Taura syndrome virus; grass carp hemorrhage virus, stomatitis, pharyngitis, colpitis, tumor, digestive tract diseases in poultry, histomoniasis, coccidiosis, human digestive tract diseases and iodine deficiency diseases.

The present invention discloses a kocuria kristinae for improving the flavor and quality of a fermented soy sauce and an application of the kocuria kristinae and relates to the field of microbial technical applications of foods. The kocuria kristinae is deposited in the China General Microbiological Culture Collection Center on November 26, 2019. The kocuria kristinae is separated from soy sauce residues of a traditional high-salt liquid-state soy source, has good salt tolerance and growth activity, is beneficial to the generation of various aroma substances such as 3-(methylthio)propionaldehyde, 1-octen-3-ol, phenylacetaldehyde and ethyl acetate in the soy sauce and is suitable for application to a traditional food fermentation process. The soy sauce prepared under the participation of the kocuria kristinae provided by the present invention is strong in sauce aroma, mellow in taste and beneficial to the further improvement of quality of the soy sauce.

The invention discloses a blended type thick broad-bean sauce essence. The blended type thick broad-bean sauce essence is prepared from 3-methylthio propanol, 3-(methylsulfanyl)propanal, ethyl lactate, ethyl caprylate, hexanal, benzaldehyde, acetic acid, propionic acid, butyric acid, isovaleric acid, caproic acid, octoic acid, piperonal, furanone, furfural, 5-methylfurfural, 4-ethylguaiacol, butyl alcohol, 1-octen-3-ol, 2,5-dimethylpyrazine, 2,3,5-trimethylpyrazine, methyl cyclopentenolone and propylene glycol. The invention further provides a preparation method of the blended type thick broad-bean sauce essence. Blending is performed according to the proportion of the formula, and the thick broad-bean sauce essence which is coordinating in aroma, vivid in flavor and mellow is obtained.

The invention relates to a method for preparing a herbicide isoxaflutole intermediate, namely, 5-cyclopropyl-4-[2-methylthio-4-(trifluoromethyl)benzoyl] isoxazole. The method comprises the following steps: condensing 3-cyclopropyl-1-(2-methylthio-4-trifluoromethylphenyl)propyl-1,3-dione and triethyl orthoformate as starting materials to prepare 1-(4-trifluoromethyl-2-methylthio-phenyl)-3-cyclopropyl-2-ethoxymethylenepropane-1,3-dione (a compound II) and enabling the compound II to react with an aqueous solution of hydroxylamine hydrochloride and inorganic base in an organic solvent to prepare 5-cyclopropyl-4-[2-methylthio-4-(trifluoromethyl)benzoyl] isoxazole (a compound I). The total yield of two steps is greater than 90.0%, the content of 5-cyclopropyl-4-[2-methylthio-4-(trifluoromethyl)benzoyl] isoxazole is higher than the 98.0% and the content of impurity is less than 0.80%; and the preparation process has the advantages of simplicity in process, low cost, mild reaction conditions and less three wastes and is suitable for industrial production.

The invention relates to a preparation method of a 2-hydroxy-4-methylthio butyric acid metal chelate. The method comprises the following steps: performing a full reaction on hydrocyanic acid mixed gas prepared from an Andrussow method and methylthio propionaldehyde under the catalytic action of an alkali so as to obtain a 2-hydroxy-4-methylthio butyronitrile reaction system; performing a hydrolytic action on the 2-hydroxy-4-methylthio butyronitrile reaction system and sulfuric acid so as to obtain 2-hydroxy-4-methylthio butyric acid; adding an aqueous medium, a metallic compound and a crystallizing agent into the 2-hydroxy-4-methylthio butyric acid; regulating a pH value to reach 5 to 7 by using the alkali; heating to reach 60 DEG C to 90 DEG C; and performing cooling crystallization, thereby obtaining a 2-hydroxy-4-methylthio butyric acid metal chelate crystal. The method is low in production cost, wherein the obtained 2-hydroxy-4-methylthio butyric acid is easy to separate and purify, so that the 2-hydroxy-4-methylthio butyric acid with the high purity and the high yield can be obtained. Thus, the 2-hydroxy-4-methylthio butyric acid metal chelate which is further prepared from the 2-hydroxy-4-methylthio butyric acid has large crystalline particles.