56 results about "Iodine catalysis" patented technology

The invention discloses an iodide ion detection reagent based on iodide catalyzed hydrazine-[oxidant-Ferroin reagent] and an iodide ion detection method. In an acid medium, a tetravalent cerium solution or potassium permanganate solution is used for oxidizing an orange red Ferroin reagent solution into a blue solution in an acid medium, and a hydrazine saline solution is added to enable the blue solution to generate a reaction that blue is slowly faded to be turned into orange red; iodine has a sensitive oxidizing effect for the reaction, the higher the iodine concentration is, the higher thereaction speed is, a proportional relation is formed between the iodine concentration and the luminance value, and the iodine content of a sample can be calculated by an iodine standard curve. The detection result can be consistent to the result of the iodine tested by adopting a classical arsenic-cerium catalytic photometric method, and the use of a virulent hard-to-purchase arsenic trioxide reagent in the classical arsenic-cerium catalytic photometric method is avoided. The detection method has the advantages of being simple and convenient, rapid, specific, sensitive, accurate and the like,is expected to be widely applied to related fields needing to detect the iodine content of the sample, and especially is applied to urine iodine and water iodine detection in the fields of sanitary inspection and medical technology.

The invention discloses a novel selenization method for an imidazopyridine derivative C3 position under the condition of elementary substance iodine catalysis, and belongs to the technical field of organic synthesis. The novel selenization method adopts elementary substance iodine as a catalyst to construct a catalytic system, and greatly expands selection of a selenium reagent in the selenizationreaction of a pyridine compound C3 position; catalysis of noble metal salt and assistance of protonic acid are not needed, the selenization reaction of the imidazopyridine derivative C3 position canbe smoothly realized under the condition of the elementary substance iodine catalysis. The novel selenization method has the characteristics that the raw material is easy to obtain, the steps are simple and easy to operate, the functional group compatibility is good, the yield is high, and the like, the novel selenization method is suitable for the selenization reaction at a C3 position of synthesizing various imidazopyridine derivatives and suitable for large-scale industrial production.

The invention discloses a method for preparing 1-oxo-1,3-dihydro-3-hydroxybenzofuran-5-formic acid. The method disclosed by the invention comprises the following steps: dissolving 2,5-toluene dihalideinto a tetrahydrofuran solution, carrying out a reaction with magnesium metal under iodine catalysis so as to obtain a corresponding Grignard reagent, and introducing carbon dioxide so as to obtain 2-methylterephthalic acid; performing chromium trioxide oxidation and diluted hydrochloric acid hydrolysis on the 2-methylterephthalic acid in the presence of glacial acetic acid, acetic anhydride andconcentrated sulfuric acid so as to prepare the 1-oxo-1,3-dihydro-3-hydroxybenzofuran-5-formic acid. The preparation method disclosed by the invention is simple in synthesis, cheap and readily available in raw material and convenient for large-scale preparation, reaction treatment in the invention is simple, and a pure target product can be obtained by virtue of washing, extracting and filtering only. Moreover, requirements on reaction instruments and equipment are simple, and since the raw materials are cheap and readily available, the method has great advantages on reaction cost, improves economic benefits and has excellent industrial prospects.

The invention belongs to the technical field of organic synthesis, discloses a method for synthesis of organophosphorus compound by photo-induced iodine catalyzed Atherton-Todd reaction. The method comprises the following steps: a compound shown as formula II and a nucleophilic reagent are subjected to reaction for 24 hours in a dichloromethane solvent, an oxygen atmosphere, under irradiation condition of room temperature and the action of a halogenated reagent I2, then the organophosphorus compound shown as the formula II is obtained through washing, drying, separating and purifying. According to the the method provided by the invention, compared with traditional Atherton-Todd reaction, no catalysis of metal is needed,no addition of alkali is needed, reaction environment such as metal, high temperature and strong base is replaced, a series of organophosphorus compounds can be synthesized by catalyzing a variety of substrates under the irradiation condition of room temperature, and hasthe advantages of good universality, short reaction time and higher yield.

The invention discloses an indole-based heterocyclic compound as well as a preparation method and application thereof in prevention and treatment of plant diseases. According to the method, indole isreacted with oxalyl chloride to obtain indole oxalyl chloride, then indole oxalyl chloride is reduced by tributylstannane to obtain indole carbonyl acetaldehyde, and finally indole carbonyl acetaldehyde is reacted with a corresponding amino acid under the catalysis of iodine to obtain a compound; or indole hydrazide is reacted with an aldehyde, and oxidizing with iodobenzene acetate is carried outto obtain the compound. The indole heterocyclic compound provided by the invention shows especially excellent plant virus resisting activity, can well inhibit the tobacco mosaic virus, and also showsbroad-spectrum plant pathogenic bacteria resisting activity.

The invention discloses a production process of high-purity aminoacetaldehyde dimethyl acetal. The process comprises the following steps: proportionally mixing chloroacetaldehyde dimethyl acetal withanhydrous liquid ammonia to react, and carrying out ammoniation, deamination recovery, alkali neutralization desalination, distillation and rectification in the presence of an iodine-containing catalyst to obtain the high-purity aminoacetaldehyde dimethyl acetal. According to the method, chloroacetaldehyde dimethyl acetal is innovatively used as a main raw material, anhydrous liquid ammonia is used as a solvent and a reaction raw material, an iodine-containing catalyst is added, and the anhydrous high-purity aminoacetaldehyde dimethyl acetal is obtained through ammoniation, deamination, alkalineutralization desalination, distillation and rectification. In practice, the technical process can reduce the generation of by-product conjugates, can realize higher conversion rate than the traditional process under the condition of higher catalytic effect, and simultaneously reduces the requirements on organic solvents and energy sources; and under the condition of the same proportion, the single-batch feeding amount and the product yield of the novel process are improved by 50% or above, the yield is about 20% higher than that of a traditional process, and the effects of saving energy, improving quality, reducing cost and reducing consumption can be achieved.

The invention discloses a new synthesis technology of benthiavalicarb isopropyl, and belongs to the field of pesticide chemistry. A method for implementing the synthesis technology comprises the steps as follows: fluorocyclohexanone is used as a raw material and catalyzed by iodine to generate 2-amino-6-fluorobenzothiazole through oxidative cyclization, and after hydrolysis and acidification, 2-amino-5-fluorothiophenol is prepared; meanwhile, D-alanine is used as a raw material and reacts with triphosgene to generate (R)-4-methyl-oxazolidine-2, 5-diketone, and an intermediate reacts with 2-amino-5-fluorothiophenol to prepare chiral (R)-1-(6-fluorine-benzothiazole-2-) ethylamine; and L-valine is used as a raw material and reacts with isopropyl chlorocarbonate to prepare N- Isopropoxy carbonyl-L-valine, carboxyl activation is performed simultaneously, and finally, the raw materials and (R)-1-(6-fluorine-benzothiazole-2-) ethylamine perform a one-pot reaction to directly generate benthiavalicarb isopropyl. The synthesis technology has short process route and high total yield, and purity degree is higher than 95%.

The invention relates to a holocellulose composite material and a preparation method thereof. Cellulose with the acetylated surface layer is prepared by adopting iodine catalysis and is adopted as a mechanical-enhancement filler fiber, and the surface of cellulosic fiber is gradually acetylated under iodine catalysis. Through the acetylation treatment of the cellulosic fiber, the compatibility ofthe cellulosic fiber and cellulose acetate is improved, but the crystallinity of the cellulose is also reduced, and the tensile strength of fiber is weakened, so that the substitution of acetyl on thefiber is controlled by the reaction time so as to balance two contrary functions, and thus the optimization is realized. The cellulose used as the mechanical-enhancement filler is partially acetylated and modified and is hot blended with plasticized CDA so as to prepare a full cellulose acetate composite material, and a matrix and a filler are provided with acetyl on the surfaces and have the similar chemical structures, so that by adding partially acetylated cellulose, the interfacial compatibility between the CDA matrix and the acetylated cellulosic fiber can be promoted to be improved, andfinally, the mechanical performance of the composite material is improved.

Provided is a method for solid phase synthesis of a vasopressin receptor peptide agonist selepressin. The method comprises the following steps: 1) sequentially coupling a solid-phase resin with amino acids protected by amino groups to synthesize a polypeptide resin H-Cys(allocam)-Phe-Ile-Hgn(Trt)-Asn(Trt)-Cys(allocam)-Pro-Org(i-Pr)-Gly-resin; 2) under solid phase conditions, removing the protective group allocam of cysteine with a ternary catalytic oxidation system and oxidizing the mercapto group into a disulfide bond; and 3) removing the resin and the protecting groups of side chains of Hgn and Asn from the cleavage broth, and purifying same. The method of the present invention does not use an iodine catalyst, greatly reduces post-processing issues, and has the advantages of simple operation, a simplified process, environmental friendliness, high economic efficiency and being suitable for large-scale production, etc.

The invention belongs to the field of synthesis of a compound, relates to a preparation method of a thiocarbamate compound, in particular to a method for synthesizing thiocarbamate through reacting ofcatalyzing three components of sodium sulfinate, isonitrile and water by iodine. The method comprises the following steps: adding the sodium sulfinate, the isonitrile and the water into ethyl acetate, then adding a molecular iodine catalyst and a phosphite reducing agent, heating, stirring and reacting for 6 to 10 hours under a condition that the temperature is 80 to 100 DEG C, and extracting, separating and purifying after finishing the reaction, thus obtaining the thiocarbamate. According to the method disclosed by the invention, the isonitrile is adopted as a carbon source, so that poisonous photogene and carbon monoxide are prevented from being used; odorless sodium sulfinate is adopted as a sulfur source, so that odorous thiophenol or thiol is prevented from being used; non-metalliciodine is adopted for catalyzing, so that a metal reagent is prevented from being used; the reaction has the advantages that the operation is simple and convenient, the technology is safe, environmentfriendliness is realized, and the like.

The invention discloses a preparation method of 2-bromo-5-chlorobenzaldehyde, which is characterized in that the steps are: a. In an inorganic strong acid solvent, control the temperature of the system to ≤10°C and slowly add 3-chlorobenzene successively dropwise Formaldehyde, iodine-containing catalyst; b. Control the temperature of the system to ≤15°C and add N-bromosuccinimide NBS several times in batches; c. After keeping the temperature for 2-10 hours, raise the temperature to 25-55°C to continue the reaction for 1- 6h; The solid product was obtained after post-processing. The present invention has one-step reaction, higher yield up to 90%, simpler operation, low cost, easy to obtain raw materials, less pollution to the environment, and only acid in the waste liquid, which can be neutralized with lye, more suitable The need for large-scale industrial production.