A related green environment-friendly leatherware cleaning agent comprises the main active compositions in parts by weight: 6-10 parts of sodium fatty alcohol polyoxyethylene ether carboxylate, 5-9 parts of fatty acid methyl ester ethoxylates, 6-10 parts of alkylethoxyglucoside, 2-6 parts of glycerin, 0.5-3 parts of diatomite, 0.1-1.5 parts of amino silicone oil, 5-10 parts of gleditsia sinensis Lam extraction liquid, 1-10 parts of propylene glycol, 0.1-1 part of sodium lactate, 0.1-1 part of a chelating agent, and 0.01-1 part of a pH conditioning agent. The invention also relates to a preparation method of the leatherware cleaning agent. According to the leatherware cleaning agent, majority of the raw materials are extracted from animals and plants, the leatherware cleaning agent is good in biodegradability, does not contain benzene and other easily-volatile toxic solvents, is green and friendly to environment. The product is mild, good in wetabiilty and strong in leather affinity; and the leatehrware cleaning agent contains diatomite, possesses friction effect when being used to clean leatherware, is strong in detersive power, does not damage leather, and possesses advantages of being efficient for washing, convenient to use, safe and the like.