The invention relates to the preparation of micro-nano materials, and aims to provide a preparation method of micro-nano 
tin dioxide 
solid spheres. The method comprises the following steps: respectively preparing a SnCl4.5H2O 
aqueous solution and a NaOH solution, uniformly dropwise adding the NaOH solution into the SnCl4.5H2O 
aqueous solution, and stirring at a high speed; transferring the 
mixed solution to a 
polytetrafluoroethylene reaction kettle, and carrying out a 
hydrothermal reaction on the 
mixed solution; carrying out 
centrifugal separation or filtering on the obtained product, washing the obtained object until no soluble 
ion exists in the solution, and 
drying, so that 
white powder is obtained; and putting the 
powder into a chamber electric furnace or a 
muffle furnace to calcine, and carrying out furnace cooling on the obtained product, so that white or light yellow 
powder, namely, micro-nano 
tin dioxide 
solid spheres, is obtained. Products prepared according to the preparation method disclosed by the invention are good in 
sphericity, smooth in surface, and uniform in size; no 
organic solvent as well as volatile poisonous gas and the like is used in the preparation process, so that only do 
sodium salts exist in products, and therefore, the product has no 
pollution to the environment; and no template is used, so that the method is simple in process, easily controlled in reaction process, mild in reaction condition, simple in 
raw material and low in cost, and therefore, the method is specially suitable for large-scale industrial production.