37 results about "Hexanedioic Acids" patented technology

A solvent composition for carbon capture is provided. According to a preferred embodiment, the solvent used for carbon capture comprises at least two of the following: diethylaminoethanol (DEAE), hexa

An aqueous ink jet ink contains a pigment, a resin and an additive. The resin has a unit containing a carboxylic acid group and a unit containing an aromatic group. The additive is at least one member selected from the group consisting of butanedicarboxylic acid, pentanedicarboxylic acid, pentanetricarboxylic acid, hexanedicarboxylic acid, hexanetricarboxylic acid, heptanetricarboxylic acid, octanetricarboxylic acid and nonanetricarboxylic acid. The content (ppm) of the additive is 180 ppm or more to 1,200 ppm or less with respect to the total mass of the ink.

The invention relates to the technical field of battery cell membranes, in particular to a battery cell insulating membrane and a preparation method thereof. The battery cell insulating film comprises the following components in parts by weight: 30-50 parts of alicyclic epoxy resin; 20 to 30 parts of bis (7-oxabicyclo [4.1. 0] 3-heptyl methyl) adipate; 15 to 25 parts of cyclohexane-1, 2-dicarboxylic acid diglycidyl ester; 10 to 15 parts of 2, 4, 5-epoxy tetrahydrophthalic acid diglycidyl ester; 5 to 10 parts of 3-ethyl-3-(hydroxymethyl) oxetane; 10 to 30 parts of bisphenol F diglycidyl ether; and 1-6 parts of a cationic curing agent. According to the invention, the alicyclic epoxy resin is matched with the epoxy resin and the photo-cation curing agent, and the formula and the curing mode are innovated, so that the problems of low automation degree, low curing speed, high energy consumption and the like in the traditional battery cell blue film production process are solved, and the method has a wide application prospect.

The present disclosure provides biosynthetic polypeptides, methods, and non-naturally occurring microorganisms, etc. for making a variety of compounds such as 1,5-pentanediol, adipic acid, 1,6-hexanediol, 6-hydroxyhexanoic acid, and 2-ketocarboxylic acids.

Abstract Disclosed are biosynthetic methods and engineered microorganism that enhance or improve the biosynthesis of hexamethylenediamine, caproic acid or caprolactam. The engineered microorganisms include selected aldehyde dehydrogenase activity. Abstract 1 / 10 wo 2020 / 219863 PCT / US2020 / 029793 +HO2C 5CoA 5CoA SUCCINYL-CoA ACETYL-CoA A A HO2C 5CoA E,F,G HO2C 002H 3-OXOADIPL-CoA 3-OXOADIPATE B H OH OH HO2C 5CoA HO2C 002H 3-HYDROXYADIPYL-CoA 3-HYDROXYDIPATE C 000000 HO2C 5CoA HO2C OO2H 3-CARBOXY-2-PENTENOYL-CoA 5-CARBOXY-2-PENTENOATE D K,L,M HOC 5CoA HO2C OO2H ADIPYL-CoA ADIPATE X N Y H Z HO2C HO2C OPO3 ADIPATE SEMIALDEHYDE ADIPYLPHOSPATE O,P HO2C NH 6-AMINOCAPROATE S Q,R CoAS NH NH T 6-AMINOCAPROYL-CoA CAPROLACTAM U H V,WNH2 H2N NH2 6-AMINOCAPROATE SEMIALDEHYDE HEXAMETYLENEDIAMINE Fig. 1 SUBSTITUTE SHEET (RULE 26) 20 26 20 48 92 24 J un 2 02 6 1 / 1 0 w o 2 0 2 0 / 2 1 9 8 6 3 P C T / U S 2 0 2 0 / 0 2 9 7 9 3 2 0 2 6 2 0 4 8 9 2 2 4 J u n 2 0 2 6 A 5 C o A E , F , G H O 2 C O O 2 H 3 - O X O A D I P L - C o A 3 - O X O A D I P A T E B H O H O H 5 C o A H O 2 C 0 0 2 H 3 - H Y D R O X Y D I P A T E C 000000 H O 2 C 5 C o A O O 2 H 3 - C A R B O X Y - 2 - P E N T E N O Y L - C o A J O O 2 H 5 C o A H O 2 C A D I P Y L - C o A A D I P A T E X N Y H Z H O 2 C H O 2 C O P O 3 A D I P Y L P H O S P A T E H O 2 C N H 6 - A M I N O C A P R O A T E S Q , R C o A S N H N H 2 T 6 - A M I N O C A P R O Y L - C o A C A P R O L A C T A M U H V , W N H H 2 N N H 2 6 - A M I N O C A P R O A T E S E M I A L D E H Y D E H E X A M E T Y L E N E D I A M I N E F i g . 1 S U B S T I T U T E S H E E T ( R U L E 2 6 )

The invention discloses a preparation method of 2, 5-dioxaadipic acid dialkyl ester, which comprises the following steps: 1, dissolving N, N '-carbonyl diimidazole in dichloromethane, dropwise adding fatty alcohol while stirring at-20 DEG C to-5 DEG C, and continuously stirring for reaction after dropwise adding; the fatty alcohol is methanol or ethanol; 2, after the reaction is finished, adding water for quenching, taking an organic phase, drying, filtering and spin-drying to obtain an intermediate imidazole carboxylic ester; 3, adding ethylene glycol, and heating and stirring for reaction; and 4, adding water for quenching, and then carrying out post-treatment to obtain a pure product. The method has the advantages that 1, the process route is simple, the reaction is easy to control, the purification difficulty is low, and the yield is high; 2, by-products are few, generated wastes are easy to treat, and the affinity to the environment is good; the raw materials are easy to obtain and can be directly purchased, the preparation cost is low, and the method is suitable for industrial production.

The application discloses a device and method for treating dimethyl sebacate electrolysis reaction products. Some by-products exist in the product of the dimethyl sebacate electrolysis reaction product after water is added to remove the solvent, the method is to add an extractant and an auxiliary agent to the reaction product and to mix and disperse through a pipeline built-in component, through the treatment, dimethyl adipate and methyl hexahydroxyhexanoate are transferred to an organic phase, and the inorganic phase is treated to meet the reuse requirements. The effect of the application is that by introducing the extractant and the auxiliary agent, the reaction product is treated by using the high-efficiency dispersion mixing structure, the process is simple, and the energy consumption is low. By using the method, the product yield can be improved, the process is simplified, the system inventory is reduced, and the method can be applied to industrial application.

The invention relates to the technical field of catalysts, and particularly discloses a preparation method and application of a catalyst for hydrogenation of dimethyl 1, 6-adipate, and the preparation method of the catalyst comprises the following steps: S1, crushing and sieving montmorillonite, carrying out acid treatment, and washing and drying after treatment; s2, dissolving szaibelyite in hot nitric acid under stirring, filtering after dissolving is completed, adding a barium hydroxide solution into filtrate, mixing and stirring, adjusting the pH value to 9.5-10.5, and aging at 50-80 DEG C; s3, uniformly mixing the montmorillonite obtained in the S1 with the material obtained in the S2 for reaction, and then filtering, washing, drying and roasting to obtain a modified montmorillonite carrier; and S4, uniformly mixing the modified montmorillonite carrier, a metal salt solution and a precipitant, standing, aging, filtering, washing, drying and calcining to obtain the modified montmorillonite catalyst. The catalyst has good catalytic performance in the reaction process of preparing 1, 6-hexanediol through hydrogenation of dimethyl 1, 6-adipate, the conversion rate of dimethyl 1, 6-adipate and the selectivity of 1, 6-hexanediol are both higher than 99%, impurities are few, the catalyst is not prone to loss, and the catalyst is green and environmentally friendly.

The invention relates to a method for preparing SSTR4 agonist compounds. A process for the preparation of SSTR4 agonist compounds via a diastereoisomer selective cyclization reaction does not require a separate epimerization step. Novel intermediates useful in the preparation of SSTR4 agonist compounds. The present invention relates to novel salts of certain SSTR4 agonists, such as salts of (1R, 5S, 6r)-N-(2-(1-methyl-1H-indazol-3-yl) propan-2-yl)-3-azabicyclo [3.1. 0] hexane-6-carboxamide succinate and salts of (1R, 5S, 6r)-N-(2-(1-methyl-1H-indazol-3-yl) propan-2-yl)-3-azabicyclo [3.1. 0] hexane-6-carboxamide adipate. Methods of treating pain, such as osteoarthritis pain, neuropathic pain, and lower back pain, by administering certain SSTR4 agonists and pharmaceutically acceptable salts thereof.

The invention belongs to the technical field of medicines, and relates to a namiklast preparation oil-in-water composition locally applied to skin as well as a preparation method and application of the namiklast preparation oil-in-water composition. Comprising the following components in parts by mass: 0.1-2 parts of namiklast, 5-10 parts of stearic acid, 10-25 parts of caprylic / capric polyethylene glycol glyceride, 5-15 parts of diisopropyl adipate, 15-30 parts of diethylene glycol monoethyl ether, 0.5-2 parts of polysorbate, 5-12 parts of glycerol, 0.2-2 parts of phenoxyethanol and 30-60 parts of purified water. The composition is applied after a mixed gas of heptafluoropropane and tetrafluoroethane is pressed in a pressure container to release foam by taking the mixed gas of heptafluoropropane and tetrafluoroethane as a propellant. The invention provides a foam type medicament which can be applied on the body surface. The foam type medicament has the advantages that foams can be effectively formed, the foam holding time is long, the foaming amount is large, the foam density is small, the foam breaking speed is slow, the particle diameter of suspended particles in the composition is stable, and the dissolving or suspending state of active medicines in liquid medicine is kept stable.

The application discloses an environment-friendly plant-based degradable high molecular material and a preparation method thereof, and relates to the technical field of high molecular materials. In the preparation of the environment-friendly plant-based degradable high molecular material, chitosan is sequentially reacted with 5-aldehyde furan-3-boronic pinacol ester and 1-bromo-1,2,2-triphenyl ethylene to obtain modified chitosan; hesperetin is reacted with 4-(chloromethyl)-1,3-dioxolane-2-ketone to obtain functionalized hesperetin; dimethyl adipate, a phosphorus-containing diacid ester monomer and 1,6-hexanediamine are subjected to polycondensation to obtain polyamide; the polyamide is reacted with formaldehyde to obtain modified polyamide; the modified polyamide, the modified chitosan, the functionalized hesperetin and 1,5,7-triazabicyclo[4.4.0]dec-5-ene are mixed and injection molded to obtain the environment-friendly plant-based degradable high molecular material. The environment-friendly plant-based degradable high molecular material prepared by the application has excellent anti-aging, flame-retardant and mechanical properties.

The present invention relates to a polyamide (PA) which exhibits a melting temperature Tm strictly less than 290°C and comprises repeating units formed by polycondensation of a diamine component (A) and a dicarboxylic acid component (B), wherein c) the diamine component (A) comprises: - 15.0 to 25.0 mol % of 1,6-hexanediamine; - 18.0 to 30.0 mol % of a diamine selected from the group consisting of 1,9-diaminononane, 1,10-diaminodecane, and a combination of said two diamines; - 50.0 to 64.0 mol % of a diamine selected from the group consisting of 1,3-bis(aminomethyl)cyclohexane, 1,4-bis(aminomethyl)cyclohexane, and a combination of said two diamines, these proportions in mol % being based on the total amount of diamines in the diamine component (A); and d) the dicarboxylic acid component (B) comprises: - 95.0 to 100.0 mol % of terephthalic acid; 0 to 5.0 mol % of another diacid selected from the group consisting of isophthalic acid, adipic acid and a combination of said two diacids, these proportions in mol % being based on the total amount of dicarboxylic acids in the dicarboxylic acid component (B) in relation to the polyamide (PA).

This invention provides a continuous preparation method for N,N,N',N'-tetra(2-hydroxyethyl)hexamethylenediamide. Diethanolamine and a sodium methoxide catalyst are mixed in a first mixer, then mixed with dimethyl adipate in a second mixer before entering a continuous reactor for synthesis. After the reaction, the crude product is passed through a falling film evaporator for further reaction and removal of unseparated methanol byproducts, yielding high-purity liquid N,N,N',N'-tetra(2-hydroxyethyl)hexamethylenediamide. Finally, the product is granulated to obtain solid, commercially available granules. This invention solves the problem of continuous production in existing technologies, offering advantages such as short synthesis time, continuous granulation, and elimination of subsequent solidification, crushing, drying, and granulation processes, thus improving equipment efficiency.

A method for preparing SSTR4 agonist compounds. A method for preparing SSTR4 agonist compounds by a diastereomer-selective cyclization reaction that does not require a separate epimerization step. Novel intermediates for preparing SSTR4 agonist compounds. Novel salts of specific SSTR4 agonists such as (1R,5S,6r)-N-(2-(1-methyl-1H-indazole-3-yl)propan-2-yl)-3-azabicyclo[3.1.0]hexane-6-carboxamide xiccinate and (1R,5S,6r)-N-(2-(1-methyl-1H-indazole-3-yl)propan-2-yl)-3-azabicyclo[3.1.0]hexane-6-carboxamide adipate. A method for treating pain such as osteoarthritis pain, neuropathic pain, and lower back pain by administering specific SSTR4 agonists and their pharmaceutically acceptable salts.

The present disclosure relates to the adipate and malonate salts of 5-((1 R,4R)-2-oxa-5-azabicyclo [2.2.1]heptan-5-yl)-N-(3-( difluoromethyl)-1-((1r,4R)-4-((4-((3-(1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1 Hbenzo[d]imidazol-4-yl)prop-2-yn-1 -yl)oxy) piperidin-1-yl)methyl)cyclohexyl)-1 H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamid, to their crystalline forms, to their preparation and to their therapeutic use.

Resins for use in toys and methods for making the same are provided. In preferred embodiments, the resins comprise 30% to 55% w / w of Ethoxylated (10) Bisphenol A Diacrylate; 20% to 35% w / w of 1,3-Hexanediol, 2-ethyl-, polymer with 1,6-diisocyanatohexane, 2-hydroxyethyl acrylate- and propylene glycol monoacrylate-blocked; 20% to 30% w / w of Hexanedioic acid, polymer with 1,2-ethanediol and 5-isocyanato-1-(isocyanatometheyl)-1,3,3-trimethylcyclohexane, 2-hydroxyethyl acrylate-blocked; 1.9%±0.5% w / w of 1-Hydroxycyclohexyl phenyl ketone; 0.43%±0.05% w / w of Ethyl trimethylbenzoyl phenylphosphinate; 0.07±0.05% w / w of Diphenyl (2, 4, 6-trimethyl benzoyl) phosphine oxide; and less than 0.19% w / w of 2-hydroxyethyl acrylate.

The invention relates to the field of preparation of hot melt adhesives, and particularly discloses a low-viscosity high-strength high-temperature-resistant bio-based single-component moisture curing reaction type polyurethane hot melt adhesive and a preparation method thereof.The polyurethane hot melt adhesive is prepared from, by weight, 10-30 parts of isocyanate, 5-20 parts of polyether glycol, 10-30 parts of polysebacic acid-1, 4-butanediol ester glycol, 10-30 parts of polyterephthalic acid-1, 4-butanediol ester glycol, 5-20 parts of polydimethylsiloxane, 5-20 parts of polydimethylsiloxane, 5-20 parts of polydimethylsiloxane, 5-20 parts of polydimethylsiloxane, 5-20 parts of polydimethylsiloxane, 5-20 parts of polydimethylsiloxane and 5-20 parts of a solvent. The adhesive is prepared from the following components in parts by weight: 10 to 40 parts of 1, 6-hexanediol ester glycol, 5 to 30 parts of poly (ethylene glycol adipate) glycol, 15 to 40 parts of bio-based polyol, 10 to 20 parts of tackifying resin and 0.05 to 0.5 part of antioxidant. The prepared polyurethane hot melt adhesive has the advantages of being good in low-viscosity wetting effect, good in later-stage bonding and wood breaking effect and good in adaptability to coating film material PVC; the method has the advantages that the universality is high, and the product is convenient to adjust.

The present invention provides methods of preparing compound of Formula (I), wherein the compounds are represented by the structure of Formula (I) wherein: R1 each is independently F, Cl, Br, I, OCH3, CN or NO2; R2 each is independently identical or different C1-C5 alkyl; n1 is an integer between 1 and 5; and n2 is an integer between 1 and 4. In addition, the present invention provides a compound represented by the following structures: Compound (1a) and Compound (2), wherein X comprises: chloride, acetate, adipate, alginate, ascorbate, aspartate, benzoate, benzenesulfonate, bisulfate, borate, butyrate, citrate, camphorate, camphorsulfonate, cyclopentanepropionate, digluconate, dodecylsulfate, ethanesulfonate, fumarate, glucoheptanoate, glycerophosphate, hemisulfate, heptanoate, hexanoate, hydroiodide, maleate, 2-hydroxyethanesulfonate, lactate, methanesulfonate, 2-naphthalenesulfonate, nicotinate, nitrate, oxalate, pectinate, persulfate, 3-phenylpropionate, phosphate, picrate, pivalate, propionate, salicylate, succinate, sulfate, sulfonate, tartrate, thiocyanate, toluenesulfonate, or undecanoate salt, or any combination thereof.

The present disclosure relates to the production of chemicals from renewable sources. The present disclosure provides, among other things, biosynthetic polypeptides, methods, and non-naturally occurring microorganisms for the preparation of a variety of compounds, such as 1, 5-pentanediol, adipic acid, 1, 6-hexanediol, 6-hydroxyhexanoic acid, and 2-ketocarboxylic acid.

This invention relates to moisture-reactive hot melt adhesive compositions prepared from combinations comprising: polyisocyanates; polyols; MA-SCA acids; one or both of inorganic fillers or organosilanes; optionally present thermoplastic polymers; and optionally present one or more additives. Available polyols include poly(hexyl adipate), polyester diols having the structure of Formula 1 or Formula 2, and combinations thereof. Formula 1 is: H-[O(CH2)] m OOC(CH2) n CO] k -O(CH2) m –OH; m and n are each even numbers; m + n = 8; m and n are each independently selected from 2, 4, or 6; k is an integer from 9 to 55; and the polyol of formula 1 has a number average molecular weight of about 2,000 to about 11,000. Formula 2, i.e., polycaprolactone polyol, is: HO-[(CH2)5COO] p -R1-[OOC(CH2)5] q -OH; R1 is an initiator, such as 1,4'-butanediol, 1,6'-hexanediol or ethylene glycol; p is an integer from 0 to 96; q is an integer from 0 to 96; p+q = 16 to 96; and the polyol has a number average molecular weight of about 2,000 to about 11,000 or less.

The invention discloses an ester hydrogenation catalyst as well as a preparation method and application thereof. The catalyst comprises zero-valence metal copper, composite metal oxide, auxiliary metal oxide and rare earth element oxide, the composite metal oxide is composed of copper oxide and manganese oxide and / or molybdenum oxide, and the auxiliary metal oxide is selected from at least two of aluminum oxide, silicon dioxide, magnesium oxide and titanium dioxide; the rare earth element is selected from at least one of lanthanum, cerium, praseodymium and rubidium. The prepared catalyst precursor powder is subjected to rare earth modification, extrusion or tabletting forming and reduction water heat treatment to prepare the catalyst suitable for a reaction for preparing dihydric alcohol through ester compound hydrogenation, the catalyst is applied to a reaction for preparing 1, 6-hexanediol through dimethyl adipate hydrogenation, and the performance of the catalyst is superior to that of an existing catalyst under the mild process condition; and the catalyst has long service life.

Among other things, the present disclosure provides biosynthesis polypeptides, methods, and non-naturally occurring microbial organisms for preparing various compounds such as 1,5-pentanediol, adipic acid, 1,6-hexanediol, 6-hydroxy hexanoic acid, and 2-keto carboxylic acids.

The invention discloses a catalyst for preparing 1, 6-hexanediol by hydrogenation of dimethyl adipate, and the catalyst comprises an active component Cu, an auxiliary component La and a carrier SiO2, the catalyst has a core-shell structure, the core of the catalyst is bimetallic Cu / La-MOF formed by adsorbing non-noble metal Cu through La-MOF coordination, and the shell layer is formed by coating the catalyst with hierarchical pore SiO2; the high-activity reaction site of the catalyst is an interface formed by Cu and LaOx. The invention also discloses a preparation method and application of the compound. In a dimethyl adipate hydrogenation reaction process, the high-performance Cu-based catalyst can realize high activity and high selectivity through an interface formed by high-activity reaction sites Cu and LaOx under a low-temperature reaction condition, has high stability, and can be stabilized for more than 1000 hours without inactivation. The catalyst is simple in preparation method, low in cost, high in catalyst activity, good in selectivity, good in stability and easy for large-scale production.

The invention relates to a Cu-based catalyst and application of the Cu-based catalyst in tandem preparation of adipic acid (ester) or hexanediol from propiolic acid (ester) or propargyl alcohol. According to the method, by constructing the copper-based catalysts in different dispersed states, the structure of the copper active species is effectively regulated and controlled, the copper active species are suitable for different reaction steps such as oxidative coupling reaction and hydrogenation reaction, and therefore the efficiency of the whole cascade reaction is improved. In the reaction process, the fully-exposed copper cluster catalyst is beneficial to promoting the oxidative coupling reaction of propiolic acid or propiolic acid ester, and the copper nanoparticle catalyst shows good hydrogenation activity and selectivity in the subsequent hydrogenation reaction. Compared with the prior art, the method has the advantages that a noble metal catalyst does not need to be used, efficient conversion from propiolic acid (ester) or propargyl alcohol to adipic acid (ester) or hexanediol can be achieved under mild conditions by reasonably regulating and controlling the dispersion state of copper species and reaction conditions, and the method has the advantages of being high in reaction selectivity, good in catalyst stability, high in environmental friendliness and the like. The method provides a green and efficient technical approach for synthesizing C6 dicarboxylic acid with high additional value and ester compounds thereof by taking acetylene and C1 raw materials as starting points, and has a good application prospect.

The application belongs to the technical field of polyamide composite materials, and specifically provides a weather-resistant and corrosion-resistant composite material for automobiles and a preparation method thereof, characterized by comprising the following steps: 1) performing an amidation reaction on dimethyl terephthalate and diamine in an inert atmosphere to obtain a precursor; 2) performing a salt formation reaction on the precursor and mixed diacids in an inert atmosphere to obtain a diamine salt; the mixed diacids are composed of 1,6-hexanedioic acid, polyether diacid and 1,3-adamantane diacetic acid; 3) performing a solid-phase polymerization reaction on the diamine salt at a solid-phase polymerization temperature in an inert atmosphere to obtain the weather-resistant and corrosion-resistant composite material for automobiles. The composite material prepared in the application has the advantages of high melting point and low water absorption.

The invention belongs to the technical field, and particularly relates to PA6T / 66 copolymerized high-temperature nylon and a production process, the PA6T / 66 copolymerized high-temperature nylon is composed of a basic comonomer, a catalyst and a functional auxiliary agent, the basic comonomer comprises the following components in percentage by mass: 42.8-45.1% of hexamethylenediamine, 30.2-35.6% of terephthalic acid and 21.2-26.6% of adipic acid, the hexamethylenediamine is pretreated by sodium bicarbonate, the catalyst is added into the basic comonomer, and the functional auxiliary agent is added into the catalyst. Terephthalic acid is subjected to surface activation and solubility modification treatment; the catalyst is a phosphite catalyst, and the addition amount of the catalyst is 0.05-0.1% of the total amount of the basic comonomer; the functional auxiliary agent comprises at least one of a compound antioxidant, an organic nucleating agent and a silane modified reinforcing agent. According to the invention, the problems of nonuniform dissolution and easy oxidation to generate impurities caused by hydrophobicity are solved through modification treatment of the copolymerized core monomers terephthalic acid and hexamethylenediamine, and appropriate process parameters are matched according to the characteristics of the modified monomers, so that the improvement of the reaction uniformity of the PA6T / 66 copolymerized high-temperature nylon and the stability of the product performance are realized.

The present invention relates to a method for determining the presence of lung cancer in a subject. The method comprises: (i) determining the level of one or more biomarkers in a sample from the subject; and (ii) comparing the level of said one or more biomarkers with the level of said one or more metabolites in a control sample to determine whether lung cancer is present in the subject. The biomarkers are selected from: 2-methoxyestrone 3-sulfate, testosterone glucuronide, androsterone glucuronide, 5a-dihydrotestosterone sulfate, corticrocin, octanoic acid, beta-citryl-L-glutamic acid, 2-hydroxymuconic semialdehyde, 5,6,11-dodecatriynoic acid, creatine riboside, 3-(Carboxymethyl)-3-hydroxypentanedioic acid, adenosine phosphosulfate, 7,8-dihydroneopterin 3'-phosphate, cis,cis,cis-10,13,16-Docosatrienoyl-CoA, inosine, N-(2,4-Dinitrophenyl)-2,4-dinitroaniline, prostaglandin M, pentadecenoic acid, PE(22:0 / P-18:0), carbamoyl phosphate, 2-hydroxy-3-oxohexanedioic acid, galactosylceramide (d18:1 / 22:0) and PE-NMe2(18:1(11Z) / 22:1(13Z)).

The present invention makes it possible to improve the production yield of 3-hydroxyhexanedioic acid, (E)-hex-2-enedioic acid, and / or hexanedioic acid while reducing the by-production of acetic acid by enhancing the function of isocitrate lyase in a microorganism capable of producing 3-hydroxyhexanedioic acid, (E)-hex-2-enedioic acid, and / or hexanedioic acid. The present invention further makes it possible to improve the production yield of 3-hydroxyhexanedioic acid by increasing the expression level of YnfM or a homolog thereof in a microorganism capable of producing 3-hydroxyhexanedioic acid.

The invention discloses a low-VOC (volatile organic compound) high-performance copolyamide hot melt adhesive, and relates to the technical field of hot-melt low-VOC materials, and the technical key point is that the low-VOC high-performance copolyamide hot melt adhesive is prepared by copolymerizing the following raw materials in parts by mass: 80-120 parts of a binary acid system, 50-100 parts of a diamine system, 0.5-2 parts of an antioxidant and 1-3 parts of a lubricant; wherein the binary acid system is a mixture of adipic acid, sebacic acid, dodecanedioic acid and tridecanedioic acid; the diamine system is a mixture of pentamethylene diamine, hexamethylenediamine and decamethylene diamine; by optimizing a binary acid-diamine quaternary / ternary compound system and combining vacuum devolatilization and precise process control, the total content of residual monomers and oligomers of the hot melt adhesive is smaller than or equal to 85 ppm and far lower than that in the prior art, the VOC release amount is only 0.27-0.32 mg / m < 3 >, the hot melt adhesive meets the environmental protection standard, and the risk of releasing harmful substances in the using process is avoided from the source.