The invention belongs to the technical field of pharmaceutical preparations, and relates to a pharmaceutical composition containing Efiniprofen, a patch and a preparation method, the pharmaceutical composition containing Efiniprofen comprises the following components in parts by
mass: 1.5-5.0 parts of Efiniprofen or pharmaceutically acceptable salts thereof, 1.0-5.0 parts of a
penetration enhancer, and 0.1-10 parts of a stabilizer; the stabilizing agent is selected from one or more of octyl and
decanoic acid coconut oil ester,
isopropyl myristate, octyl and
decanoic acid polyethylene glycol
glyceride,
polyethylene glycol-7
stearate and
glyceryl monostearate and
glyceryl distearate. According to the invention, the content reduction of the efiniprofen or the pharmaceutically acceptable salt during the stability period is effectively inhibited, and the stability is further improved, so that the pharmaceutical composition containing the efiniprofen can be stored for a long time; meanwhile, the in-vitro release effect of the pharmaceutical composition containing the iflurprofen is further improved.