The invention discloses a method for preparing isopropyl acetate through reaction of propylene and acetic acid. The method is characterized by comprising the following steps: (A) mixing an inert component with propylene and acetic acid, and feeding into a fixed bed reactor for reaction; (B) feeding the reacted mixture into a heavy component removal tower for removing heavy components; (C) condensing the tower top product of the heavy component removal tower, feeding into a light component removal tower for further separation, condensing the tower top product of the light component removal tower, feeding back a part of the condensed product to the tower top for backflow, feeding back a part of the condensed part to a reaction system for recycling and reuse, and discharging out an isopropyl acetate product from a side line of the column bottom. By adopting the method, the reaction acid-alkene ratio is reduced, the operation pressure of the reaction system is reduced, the treatment capacity of the heavy component removal tower is increased, the energy consumption is reduced, conventional processes and equipment can be used, propylene which is discharged out at present can be effectively recycled, the material consumption is reduced, the influence caused by discharged propylene to the environment is reduced, the potential safety hazard is eliminated, the separation process procedures are shortened, and the equipment investment is reduced.