The invention discloses a multi-effect organic cooling liquid composition and application thereof. The multi-effect organic cooling liquid composition comprises four components, wherein the four components are composed of any four of hexafluoropropylene dimer, hexafluoropropylene trimer, perfluorohexanone, perfluoroheptane, perfluorooctane, perfluoropentane, perfluorohexane, perfluorotripropylamine, perfluorotributylamine, perfluorotripentylamine, perfluoro-N-methylmorpholine and the like. The cooling liquid composition can achieve corrosion protection of multi-metal materials and welding fluxin liquid cooling systems such as radar and electronic laser, has good adaptability to non-metal materials and long service life, is free of corrosion and pollution, can be used in the environment of65 DEG C below zero to 115 DEG C, is non-conductive or low in conductivity, is nonflammable but easy to clean, has a good cooling effect in the fields of electronic radars, electronic lasers and thelike, and can be applied to cooling systems of low-temperature environment equipment such as radars, lasers, etc.