61 results about "P-toluene sulphonic acid" patented technology

The ester ether compound with high acidolysis activity is synthesized through the reaction between benzil acid (2,2-diphenyl glycolic acid) and phenols, each of which has at residual active point in its benzene ring, in the presence of p-toluene sulfonic-acid catalyst in 0.1-2 % and methyl benzene, dimethyl benzene and other benzene compound as solvent to synthesize a serial addition compound of benzil acid and phenols which may be further dewatered to produce lactone compound; and the etherification of the said addition compound or the lactone compound the ether compound, such as vinyl ethylether, dihydropyran, dihydrofuran, dihyidropyrrole, etc. at below 70 deg.c. The ester ether compound may be used as photothermal imaging information record material.

The invention relates to a poly-pyrrole modified electrode doped with p-toluene sulphonic acid and provides a method using the modified electrode for rapidly detecting the content of vitamin E. the method comprises: 1) using experimental conditions which are the same with the detecting conditions of a sampler for drawing a standard curve of the content of vitamin E and oxidation peak current; 2) dissolving the sample in the mixed solvent of ethanol-1 and 2 dichloroethane and regulating the pH value to be 2-5 to obtain the sample solution; 3) arranging the modified electrode in the sample solution, detecting the oxidation peak current through a differential pulse voltammetry and calculating the concentration of vitamin E in the sample. The method can be used for rapidly detecting the content of vitamin E in vegetable oil and has the advantages of simple sample preparation, convenience, fast speed, strong anti-interference ability and accurate detecting result which is identical with the detecting result of a liquid chromatography.

The invention relates to a new synthetic method of a PET imaging agent L-5-<18>FETP. The method comprises the following steps: (a) carrying out a reaction between 5-hydroxytryptophan and C<1-3>alkylolto obtain a product; carrying out a reaction between the product and di-tert-butyl (i.e. (BOC)2O) to obtain N-BOC-L-5-hydroxytryptophan; (b) fluorizating 1,2-glycol tosylate in the presence of the ions such as potassium carbonate, Kryptate2.2.2 and <18>F<-> to obtain 2-<18F>-fluoroethanol p-toluene sulphonic acid ester (i.e. <18>FCH2CH2OTs); (c) carrying out a reaction between the 2-<18F>-fluoroethanol p-toluene sulphonic acid ester and the alkali metal salt of the N-BOC-L-5-hydroxytryptophan (such as sodium salt) to obtain O-(2-<18F>fluoroethyl)-N-BOC-L-5-hydroxytryptophan; (d) hydrolyzing the O-(2-<18F>fluoroethyl)-N-BOC-L-5-hydroxytryptophan under acidic conditions to remove an amino group and a carboxy protective group and obtain a final product of O-(2-<18F>fluoroethyl)-N-BOC-L-5-hydroxy tryptophan; and (e) purifying the product. The method greatly improves the radiochemical yield, obtains a sufficient quantity of a target product and realizes the clinical application of the target product.

The present invention discloses a polycarboxylic acid base water reducer, which comprises, by weight, 50-80 parts of PEG, 10-30 parts of a carboxy-containing dicarboxylic acid monomer, 40-60 parts of hydroxyethyl acrylate, 100-120 parts of melamine, 1-3 parts of p-toluene sulfonic acid, 5-8 parts of sodium hydrogen sulfate, 20-50 parts of an initiator, and 100-130 parts of water. The polycarboxylic acid base water reducer has characteristics of excellent performance and easy use, can be directly incorporated into concrete while the concrete performance is not affected, can be provided for making cement paste have good fluidity, can not produce clogging during pumping, is convenient during transportation, and further has characteristics of environmental protection, no formaldehyde harmful for environment and human body, low acidity, almost no corrosion on steel bar, and effective concrete strength and durability improvement.

The invention relates to the technical field of medicine, in particular to a preparation method of epinastine hydrochloride. The preparation method comprises the following steps: performing substitution reaction of a compound with a structure as shown in formula (II) and a compound with a structure as shown in formula (III) in an organic solvent, so as to produce a compound with a structure as shown in formula (IV); cyclizing the compound with the structure as shown in formula (IV) in the organic solvent in the presence of p-toluene sulphonic acid, so as to produce a compound with a structure as shown in formula (V); and then salifying the compound with the structure as shown in formula (V), so as to produce a compound with the structure as shown in formula (I). Thus, cyanogens bromide which is used in the traditional preparation method is prevented from being used in the cyclizing reaction, and therefore the toxicity of the preparation method is reduced. The operation of the preparation method is safer and more environment-friendly.

The invention relates to an environmental-friendly rubber homogenizing agent. The environmental-friendly rubber homogenizing agent is prepared from the following components in parts by weight: 70-90 parts of modified petroleum asphalt, 10-30 parts of carbon-hydrogen resin and 1.5-2 parts of p-toluene sulphonic acid, wherein the modified petroleum asphalt is prepared from the following components in parts by weight: 70-90 parts of petroleum asphalt, 1.5-2 parts of phosphoric acid and 10-25 parts of a modifier. The environmental-friendly rubber homogenizing agent has the beneficial effects that comprehensively considering from environmental protection property and using property of a product, at higher temperature, air, the modifier and asphalt component generate chemical reaction in the uniformly mixing process by utilizing oxidation of the air and chemical modification of the modifier, and then the amount of polycyclic aromatic hydrocarbons carcinogen is reduced when the amount of softening point of asphalt is remarkably increased; selected formula system and preparation method can reach good effect, and the acquired homogenizing agent is low in polycyclic aromatic hydrocarbons content and accords with the requirement of European Union REACH Regulations; meanwhile, with the adoption of the environmental-friendly rubber homogenizing agent, blending uniformity of rubber can be remarkably improved, mixing quality is improved, and energy is saved, thus increasing technical content and added value of the product.

The invention provides an anion receptor based on 5-nitrofuran formyl hydrazone and phenolic hydroxyl. The anion receptor is obtained by mixing 2, 6-dimethylacyl-4-chlorophenol and 5-(4-nitro)-phenyl-2-benzoyl diazanyl furan according to certain proportion, stirring and refluxing the mixture for 3 to 8 hours at a temperature of between 70 and 100 DEG C by using anhydrous ethanol as a solvent and p-toluene sulfonic acid as a catalyst, distilling out most of the solvent through reducing the pressure, performing suction filtration after cooling, and performing recrystalization on the solid product by using DMSO-EtOH. The anion receptor has color comparison recognizing ability on fluorion, acetic acid radical and phosphoric acid dihydrogen radical in a DMSO solution. The anion receptor is dissolved in DMF to be prepared into 0.5 to 2.0 percent of solution which is cooled to room temperature to be prepare into stable anion receptor organic gel used for performing colorimetric detection on the fluorion, and the acetic acid radical and phosphoric acid dihydrogen radical ions in the DMSO solution. The anion receptor has the advantages of convenience for carrying, convenient use, high detection sensitivity and the like.

The present invention discloses an imidazolyl bionic ionic liquid preparation method, which comprises that: (1) a natural alcohol perfume and p-toluene sulfonyl chloride are adopted as raw materials, dichloromethane is adopted as a solvent, triethylamine is adopted as an acid binding agent, and a reaction is performed at a temperature of less than or equal to 10 DEG C under the catalysis effect of dimethyl amino pyridine to prepare a p-toluene sulfonic acid ester compound; (2) an imidazole compound and the p-toluene sulfonic acid ester compound are subjected to a nucleophilic substitution reaction at a room temperature to prepare an imidazole p-toluene sulfonate intermediate; and (3) the p-toluene sulfonate ions in the imidazole p-toluene sulfonate intermediate are substituted into the hydroxy radical ions by using an anion exchange resin, and the obtained material and an acid are subjected to a neutralization reaction to change the anion of the ionic liquid so as to prepare the target product imidazolyl bionic ionic liquid. According to the present invention, the preparation method has characteristics of low raw material price and high product purity, the high biocompatibility of the bionic ionic liquid is utilized, the method can be used for preparation of biosensors, and the application range of the class of the ionic liquids in the biological field is expanded.

The invention discloses a leather-based preparation method of electrocardiogram monitoring dry electrode, which comprises the following steps: dropwise adding a pyrrole monomer onto a dry flexible leather substrate to uniformly overspread leather with the pyrrole monomer, then dropwise adding a ferric chloride solution and a PTSA (p-toluene sulphonic acid) solution, and performing standing for 0.5to 4h under an ice bath condition to obtain leather immobilized with pyrrole on the surface; washing the obtained leather immobilized with the pyrrole with purified water, and drying the leather to obtain an electrocardiogram monitoring dry electrode prepared on the basis of the leather. The self impedance of the leather dry electrode obtained by the method is higher than that of a standard commercial electrode. The preparation method for the leather dry electrode is simple and mild in preparation condition, and has far-reaching significance on further development and popularization of flexible electrodes and flexible electrons.

The invention relates to a synthesis method of Alpha-keto-based enamine derivative cooling agent (3-MPC), which is characterized in that methyl-cyclopentene alcohol ketone and pyrrolidine are taken as raw materials and mixed by mass ratio of 1:1.8-2.0, and catalyst p-toluene sulphonic acid is added by 0.2-0.5 percent of the mass ratio of cyclopentene alcohol ketone and pyrrolidine, refluxed through solvent, and water is added when the solvent is steamed, pH value is regulated by NaOH solution to be approximately equal to 9, then the reaction solution is extracted by ether, after extraction, the organic layer is combined and washed by Na2CO3 solution, then the solvent is dried by anhydrous Na2SO4 and steamed, thereby acquiring brown-yellow oily liquid which is processed by column chromatography with alkali alumina, and light yellow oily liquid Alpha-Keto-based enamine derivative cooling agent product is acquired. The non-menthol cooling agent 3-MPC synthesized by the invention is implemented by certain concentration into cut tobacco of cigarettes, toothpaste and chewing gum and has the effects of even cool taste which lasts for a long time and prominent comfortable feeling, etc.

The invention discloses a high-toughness water-based ceramic coating. The coating is a water-based, single-component, baked and dried product and is prepared from polyurethane modified nano ceramic emulsion, silicon resin emulsion, a high-temperature-resistant pigment, a filler, auxiliaries, an ammonium toluene-4-sulphonate neutralizer and water. The coating is convenient to construct and extremely low in coating VOC emission, has excellent flame retardance, heat resistance, corrosion medium shielding, bending resistance and impact resistance, and is an excellent choice for high-temperature-resistance and high-durability anti-corrosion protective coating.

Disclosed is a method of manufacturing a surface-treated transparent conductive polymer thin film, including: 1) preparing a PEDOT:PSS ink composition; 2) forming a PEDOT:PSS thin film on a substrate using the ink composition; 3) applying a p-toluene sulfonic acid solution on the PEDOT:PSS thin film and then thermally treating the PEDOT:PSS thin film; 4) rinsing the thermally treated PEDOT:PSS thin film; and 5) drying the rinsed PEDOT:PSS thin film.

A solid electrolyte and a capacitor thereof are provided in order to improve the conductivity and service life of the current capacitor. The invention provides an electrolyte which is prepared with 3,4-ethoxylene dioxy thiophene, graphene, Iron(III) p-toluene sulfonate hexahydrate, and block copolymer polyethylene glycol-Poly(sodium-p-styrenesulfonate). In addition, the invention provides a capacitor prepared with the electrolyte. The solid electrolyte and the capacitor have the beneficial effect that the conductive composite material used as the solid electrolyte has excellent electrical conductivity, the precursor dispersion liquid thereof can easily go into the holes of a pole piece isolation layer and a formed foil of an electrolytic capacitor, the material is suitable for being used as the electrolyte for capacitors, and the capacitor made from the electrolyte has low equivalent series resistance and long life.

The present invention discloses a polycarboxylic acid base water reducer preparation method, which comprises: adding 10-30 parts of a carboxy-containing dicarboxylic acid monomer, 40-60 parts of hydroxyethyl acrylate and 100-120 parts of melamine to a reaction kettle, carrying out stirring heating, carrying out a reaction for 2-4 h at a temperature of 90-120 DEG C to obtain a transparent liquid so as to be spare; and pouring 50-80 parts of PEG, 1-3 parts of p-toluene sulfonic acid, 5-8 parts of sodium hydrogen sulfate and 100-130 parts of water to another reaction kettle, heating to achieve a temperature of 60-70 DEG C, adding 20-50 parts of an initiator, heating, adding the transparent liquid in a dropwise manner when the temperature is controlled to 80-90 DEG C, and continuously carrying out the reaction for 2-3 h after completing the transparent liquid addition to obtain the polycarboxylic acid base water reducer. According to the present invention, the process is simple, the reaction conditions are easy to control, and no pollution is generated during the production process; and the product prepared by using the preparation method has characteristics of excellent performance, easy use and environmental protection.

The invention discloses a concrete water reducer and a preparation method thereof. The water reducer is synthesized by using raw materials including vegetable oil, acrylic acid, methoxy polyethylene glycol, an initiator, p-toluene sulphonic acid, concentrated sulphuric acid, p-dihydroxybenzene and an emulsifying agent through esterification, wherein the synthesis method is mainly realized through the steps of stirring, mixing, controlling the temperature to carry out esterification reaction, regulating the pH value and the like. The preparation method is simple in process flow and easy to operate; meanwhile, the water reducer provided by the invention is small in mixing amount, high in water reducing rate, low in cost and environment-friendly.

A biodiesel composite catalyst consists of dodecylbenzene sulfonic acid and p-toluene sulphonic acid, wherein, the dosage of the dodecylbenzene sulfonic acid is 60-80 percet; the dosage of the p-toluene sulphonic acid is 20-40 percent; the raw materials only need to be stirred uniformly under normal temperature and pressure. The composite catalyst made by adopting the present invention has very strong catalytic activity in the esterification reaction process of oil and methanol, and has a certain emulsification to the oil and the methanol, which is beneficial to promote the oil and the methanol to contact closely and can greatly improve reaction efficiency.

The invention belongs to the field of medicines, and particularly relates to a preparation method and application of bicyclol. The preparation method comprises the following steps: adding bicyclol acid and alkali into a reaction solvent; adding a methyl p-toluene sulfonate solution; and carrying out reactions to obtain bicyclol. According to the provided preparation method, a new methylation reagent namely methyl p-toluene sulfonate is adopted; and a methylation reagent, which is toxic and explosive, is difficult to buy, and is dangerous during the application process, is not used. The defectssuch as difficult post-treatment, low yield and the like caused by adopting a methylation reagent which is toxic and explosive are overcome. Prodrugs meeting the quality requirements can be preparedthrough simple process operation and mild experimental conditions, and the yield is high. The method is stable in process yield, has reproducibility and reliability and is suitable for industrial production.

The invention relates to a method of synthesis of N-alkyl p-toluene sulfonamide. In the presence of a PIMs supported solid super acid catalyst, a reaction between anhydrous p-toluene sulfonamide and a primary amine is carried out in the presence of a water absorber 5A-type molecular sieve to obtain a target product. The conversion rate of the anhydrous p-toluene sulfonamide reaches 81.90%, and the yield of the N-alkyl p-toluene sulfonamide can reach 70.53%. The method has high catalyst yield and mild reaction conditions. The catalyst is easy to recycle. The method is low in environment pollution.

The invention discloses a preparation method for anti-HIV active sulfonic acid based bagasse xylan p-ferrocene benzoate. The preparation method comprises the following steps: with bagasse xylan as a raw material, sodium trisulphamidate as an esterifying agent of a reaction in a first step, and p-toluene sulphonic acid as a catalyst, carrying out an esterification reaction and hydrochloric acidizing treatment in an aqueous phase so as to obtain sulfonic acid based bagasse xylan, and determining the substitution degree of sulfation; and on the basis of synthesizing the sulfonic acid based bagasse xylan, and with p-ferrocene based benzoic acid as the carboxylating agent in a second step and phosphomolybdic acid as a catalyst, and carrying out an esterification reaction with the sulfonic acidbased bagasse xylan in a chloroform solvent so as to synthesize the sulfonic acid based bagasse xylan p-ferrocene benzoate. The preparation method has the following advantages: the sulfonic acid basedbagasse xylan p-ferrocene benzoate obtained by using the method provided by the invention has the biological activity of bagasse xylan sulfate; meanwhile, the anti-biological activity of p-ferrocenebenzoic acid is introduced; characteristics like high raw material utilization rate and stable product quality are obtained; and important application values in fields like biology, medicine and functional materials are realized.

The present invention provides an efficient non-oxidizing bactericide and a preparation method thereof. The raw materials comprise, by weight, 2-6 parts of maleic anhydride, 3-7 parts of 2-octanol, 2-6 parts of p-toluene sulfonic acid, 5-8 parts of sodium bisulfite, 17-23 parts of sodium n,n-dimethyl dithiocarbamate, 4-6 parts of a biological dispersant 508, 12-18 parts of hydroxy propyl methacrylate, and 20-47 parts of desalted water. The preparation method comprises: sequentially pouring maleic anhydride, 2-octanol and p-toluene sulfonic acid to a reaction kettle, carrying out stirring heating under a condition of 60-80 rpm to achieve a temperature of 120-140 DEG C, carrying out an esterification reaction, maintaining a constant temperature for 1.9-2.3 h, cooling the material to a temperature of 100-105 DEG C, adding sodium bisulfate, carrying out sulfonation under stirring, controlling the pH value of 7.0-9.5, carrying out a reaction for 3-7 h, cooling the material to a temperature of 20 DEG C, sequentially adding sodium n,n-dimethyl dithiocarbamate, a biological dispersant 508, hydroxy propyl methacrylate and desalted water, continuously stirring for 28-32 min, and filtering with a 200 mesh sieve to obtain the product.

The invention provides a preparation process of triolein, relating to the technical field of chemical engineering. The preparation process comprises the following steps: weighing glycerol and oleic acid of which a certain molar ratio is (2.3-3.2):1; weighing a catalyst the amount of which is 0.1%-1% of the total weight, wherein the catalyst is p-toluene sulphonic acid, solid super strong acid, self-made catalyst and the like; adding glycerol, oleic acid and the catalyst in a reactor, raising the temperature of the reactor, keeping reaction temperature to 140-220 DEG C, and carrying out reaction for 4-8h; and after the reaction is finished, carrying out vacuum dehydration on a reactant by utilizing a vacuum dehydration machine until an acid value reaches the standard, wherein the standard is as follows: the appearance of the reactant is pale yellow supernatant liquid, acid value/(mgKOH/g) is not larger than 2, hydroxyl value/(mgKOH/g) is 185-205, saponification value/( mgKOH/g) is not larger than 25, and moisture is not larger than 1. With the adoption of the preparation process, the triolein can be conveniently obtained, and preparation cost is lowered.

The invention provides a preparation method of a high-energy graphene battery negative electrode material. The method comprises the steps that Si-B-Co co-doped graphene oxide, carbon fiber-quartz fiber composite fiber are added at a mass ratio of 1: 0.1 to 0.2 in to a toluene sulfonic acid aqueous solution and heated; ethyl orthosilicate is quickly added, and toluene is slowly added dropwise whilestirring is carried out to acquire gel; and ageing, reduction and freeze drying are carried out to acquire the high-energy graphene battery negative electrode material. According to the invention, Si-B-Co co-doped graphene oxide, carbon fiber-quartz fiber composite fiber are used as raw materials to perform gelation treatment to generate a rich-pore structure and provide more lithium storage sites; graphene-doped micro individuals in the acquired negative electrode material form a bridge network structure through composite fiber, providing more diffusion channels for lithium ions and achieving rapid insertion and deintercalation of lithium ions; the diffusion rate of lithium ions in the negative electrode material is enhanced; and the acquired negative electrode material has higher firstCoulomb efficiency and good cycle performance.

The invention relates to a gum rosin-containing waterproof antistatic aluminium alloy coating, which is composed of the following components by weight ratio: 11-17 parts of gum rosin, 4-6 parts of polyamide 612, 7-15 parts of propylene glycol methyl ether acetate, 1-3 parts of p-toluene sulphonic acid, 1-2 parts of magnesium bromide, 3-5 parts of hexamethylene tetramine, and 1-3 parts of barium sulfate. The prepared aluminium alloy coating has waterproof and antistatic advantages, and can be used in clean workshop aluminium alloy windows.