The invention belongs to the technical field of construction, and relates to a full prefabricated pre-stress assembly type structure and a construction method thereof. The full prefabricated pre-stress assembly type structure is characterized in that a structural main body is of a frame structure; columns, beams, plates, doors and windows, walls and stairs are prefabricated by factories; grooves and holes are formed in the columns, beams, and plates according to a total design drawing, the quality of components can be ensured, complex operations such as template supporting, maintenance and demounting can be avoided in a construction site, and the full prefabricated pre-stress assembly type structure can save labors, is high in efficiency, is good in quality, is light and convenient, and can avoid construction pollution; compared the conventional assembly type structures, the full prefabricated pre-stress assembly type structure is characterized in that the assembly and stability are excellent; the size of a desired cross section is small at the request of an equal bearing capacity design value, and the anti-shock performance can be ensured. The full prefabricated pre-stress assembly type structure is environment-friendly, can save energy and reduce consumption, can meet the demand of a sustainable development strategy of the construction industry, can be widely used for variousmultiple high frame structures, and can achieve good economic and social benefits.