The invention discloses dedicated chemical fertilizer for grape. The dedicated chemical fertilizer is prepared from the following components in parts by weight: 25 to 30 parts of nitrogen fertilizer, 10 to 15 parts of phosphate fertilizer, 20 to 25 parts of potash fertilizer, 8 to 10 parts of magnesium sulfate, 20 to 30 parts of straw, 8 to 10 parts of sugar beet pulp, 5 to 10 parts of boron-magnesia fertilizer, 3 to 5 parts of zinc sulfate, 1 to 3 parts of chelate zinc, 3 to 5 parts of copper amino acid chelate, 3 to 5 parts of ammonium ferrous sulfate, 3 to 5 parts of humic acid, 3 to 5 parts of manganous sulfate, 3 to 5 parts of ammonium molybdate, 3 to 5 parts of amino acid, 1 to 3 parts of cnidium lactone and the like. The invention belongs to the technical field of agricultural fertilizer, and particularly provides the dedicated chemical fertilizer for the grape, which is comprehensive and balanced in nutrient, high in pertinence, and capable of effectively improving the structure of soil, increasing the yield of the grape, preventing and controlling plant diseases and insect pests and improving freezing resistance of grape plants, and a preparation method of the dedicated chemical fertilizer.