The invention discloses mixed gel skeleton
ibuprofen cataplasm and a preparation technique thereof and belongs to the technical field of medicines. The mixed gel skeleton
ibuprofen cataplasm preparation is mainly composed of
raw material drugs (non-steroidal anti-inflammatory
drug ibuprofen and the slat form thereof ), mixed gel skeletons (
sodium polyacrylate, crosslinked
sodium polyacrylate and the like), plasticizers (
sodium alginate, polyving akohol,
polyethylene glycol,
triethyl citrate and the like), thickening agents (
polyvinylpyrrolidone, carbomer, methylcellulose,
ethyl cellulose and the like ), humectants (
glycerol,
sorbitol,
propylene glycol, 1,3-
butanediol and the like), pH regulators (
citric acid,
tartaric acid,
lactic acid and the like ), penetration enhancers (
menthol,
diethylene glycol monoethyl
ether, octanoic acid
capric acid polyethylene glycol
glyceride,
polyethylene glycol
glyceride and the like), water, a backing layer and a release film. The mixed gel skeleton ibuprofen cataplasm and the preparation technique thereof have the following characteristics that (1) the
drug loading capacity of the preparation is high, the main
drug and addition agents are stable in a hydrogel mechanism and low in drug blocking performance, the preparation can be released continuously for 12 hours, and the residual drug amount is less after using; (2) organic solvents are not used in a prescription and in the preparation process, so that
skin irritation is avoided; (3) good adhesiveness is achieved, and residues are avoided at the time of peeling; and (4) the preparation process is simple and convenient to implement, and
pollution is avoided.