The invention discloses a synthetic method of medicinal
acetyl trioctyl citrate, in particular to a method for catalytic synthesis of
acetyl trioctyl citrate by using of mesoporous
zeolite supported heteropolyacid. The synthetic method comprises the following steps: (1),
citric acid and n-caprylic
alcohol are used as raw materials, mesoporous
zeolite supported heteropolyacid is used as catalyst, after complete reaction, the obtained reaction mixture
layers naturally, and n-caprylic
alcohol and water in the mixture are distilled out under reduced pressure directly to obtain a crude product; (2), adding
acetic anhydride into the crude product obtained in step (1), after complete reaction, the reaction mixture is left to stand for layering, the substance in the upper layer is subjected to
distillation under reduced pressure to obtain a coarse product, and the coarse product is refined and purified to obtain the finished product of
acetyl trioctyl citrate. The method provided by the invention is mild in reaction condition and short in reaction time; the same catalyst is used in the reaction of two steps and can be reused, so that the method is suitable for industrial production; besides, the product esterification rate is high, the product yield is high, the quality is good, and the microbial limit is controlled effectively.